Studying Microstructure in Molecular Crystals With Nanoindentation: Intergrowth Polymorphism in Felodipine

被引：76

作者：

Mishra, Manish Kumar ^{[1
]}

Desiraju, Gautam R. ^{[1
]}

Ramamurty, Upadrasta ^{[2
,3
]}

Bond, Andrew D. ^{[4
]}

机构：

[1] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Mat Engn, Bangalore 560012, Karnataka, India

[3] King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Jeddah 21589, Saudi Arabia

[4] Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen O, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 48期

关键词：

crystal engineering; microstructure; nanoindentation; polymorphism; X-ray diffraction; FORM-II; ASPIRIN;

D O I：

10.1002/anie.201406898

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Intergrowth polymorphism refers to the existence of distinct structural domains within a single crystal of a compound. The phenomenon is exhibited by form II of the active pharmaceutical ingredient felodipine, and the associated microstructure is a significant feature of the compound's structural identity. Employing the technique of nanoindentation on form II reveals a bimodal mechanical response on specific single-crystal faces, demonstrating distinct properties for two polymorphic forms within the same crystal.

引用

页码：13102 / 13105

页数：4

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