Novel regulators of spermatogenesis

被引：34
作者：
Fok, Kin Lam [1 ]
Chen, Hao [1 ]
Ruan, Ye Chun [1 ]
Chan, Hsiao Chang [1 ]
机构：
[1] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Epithelial Cell Biol Res Ctr, Hong Kong, Hong Kong, Peoples R China
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2014年 / 29卷
关键词：
Spermatogenesis; CFTR; CD147; YWK-II; STK31; NYD-SP8; TRANSMEMBRANE CONDUCTANCE REGULATOR; SPERMATOGONIAL STEM-CELLS; MULLERIAN-INHIBITING SUBSTANCE; CYSTIC-FIBROSIS MUTATION; HUMAN HEPATOMA-CELLS; ECTOPLASMIC SPECIALIZATION DYNAMICS; HEPATOCELLULAR-CARCINOMA CELLS; CONGENITAL BILATERAL ABSENCE; BLOOD-TESTIS BARRIER; VAS-DEFERENS;
D O I：
10.1016/j.semcdb.2014.02.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Spermatogenesis is a multistep process that supports the production of millions of sperm daily. Understanding of the molecular mechanisms that regulate spermatogenesis has been a major focus for decades. Yet, the regulators involved in different cellular processes of spermatogenesis remain largely unknown. Human diseases that result in defective spermatogenesis have provided hints on the molecular mechanisms regulating this process. In this review, we have summarized recent findings on the function and signaling mechanisms of several genes that are known to be associated with disease or pathological processes, including CFTR, CD147, YWK-II and CT genes, and discuss their potential roles in regulating different processes of spermatogenesis. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：31 / 42
页数：12
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