Rapid identification of limonoids from Cipadessa baccifera and Xylocarpus granatum using ESI-Q-ToF-MS/MS and their structure-fragmentation study

被引：20

作者：

Kumar, K. ^{[1
,2
]}

Siva, Bandi ^{[1
]}

Rao, N. Rama ^{[2
]}

Babu, K. Suresh ^{[1
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Div Nat Prod Chem, Nat Prod Lab, Hyderabad 500007, Andhra Pradesh, India

[2] Chalapathi Inst Pharmaceut Sci, Guntur 522034, Andhra Pradesh, India

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2018年 / 152卷

关键词：

Cipadessa baccifera; Xylocarpus granatum; Meliaceae; ESI-Q-ToF-MS/MS; MASS-SPECTROMETRY; NATURAL-PRODUCTS; MANGROVE; MEXICANOLIDE; CHEMISTRY; LEAVES; FRUIT; SEEDS;

D O I：

10.1016/j.jpba.2017.12.050

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Limonoids found to be chemotaxonomic markers from the plants of the Meliaceae and Rutaceae families. In the present study, rapid identification of limonoids from Cipadessa baccifera and Xylocarpus granatum were achieved using fast and simple electrospray ionization quadruple time-of-flight mass spectrometry (ESI-Q-ToF-MS/MS) in positive-ion mode. Although the structures of these compounds were found to be similar, Collision Induced Dissociation (CID) mass spectrometric analysis of these protonated/sodiated molecules indicated different fragmentation patterns by which the structures were confirmed. The fragment ions were formed due to the loss of neutral components like H2O, CO2, methanol, as well as McLafferty rearrangement and Retro-ene reaction. Furthermore, MS/MS spectra revealed different fragmentation pathways for different classes of limonoids which further aided dereplication. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：224 / 233

页数：10