Synthesis and characterization of a new lanthanide based MRI contrast agent, potential and versatile tracer for multimodal imaging

被引：11
作者：
Chilla, Satya Narayana Murthy [1 ,2 ]
Laurent, Sophie [1 ,2 ]
Elst, Luce Vander [1 ,2 ,3 ]
Muller, Robert N. [1 ,2 ,3 ]
机构：
[1] Univ Mons, Dept Gen Organ & Biomed Chem NMR, B-7000 Mons, Belgium
[2] Univ Mons, Mol Imaging Lab, B-7000 Mons, Belgium
[3] CMMI, B-6041 Gosselies, Belgium
来源：
TETRAHEDRON | 2014年 / 70卷 / 35期
关键词：
Imaging agents; Macrocyclic ligands; Gadolinium; Relaxivity; Gd-DOTA; ALKALINE-EARTH METAL; FAST WATER EXCHANGE; COMPLEXES; GADOLINIUM; RELAXIVITY; DESIGN; SENSITIVITY; MODULATION; STABILITY; LIGANDS;
D O I：
10.1016/j.tet.2014.06.126
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the present work a modular pathway towards the synthesis of a new versatile MRI contrast agent is reported and its physico-chemical properties are described. Two different functional groups were attached on two arms of the gadolinium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA) in order to get a platform able to bind one probe designed to target specific biological marker and a fluorescent molecule likely to be used for optical imaging. The nuclear magnetic relaxation dispersion (NMRD) profile, the oxygen-17 relaxometric NMR study and stability assessment versus transmetalation of the Gd-complex show that this new contrast agent has a relaxivity and transmetalation stability similar to Gd-DOTA. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5450 / 5454
页数：5
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