Resistance to irinotecan (CPT-11) activates epidermal growth factor receptor/nuclear factor kappa B and increases cellular metastasis and autophagy in LoVo colon cancer cells

被引：28

作者：

Chen, Ming-Cheng ^{[1
,2
]}

Lee, Nien-Hung ^{[1
]}

Ho, Tsung-Jung ^{[3
]}

Hsu, Hsi-Hsien ^{[4
,5
]}

Kuo, Chia-Hua ^{[6
]}

Kuo, Wei-Wen ^{[7
]}

Lin, Yueh-Min ^{[8
,9
]}

Tsai, Fuu-Jen ^{[10
]}

Tsai, Chang-Hai ^{[11
]}

Huang, Chih-Yang ^{[1
,10
,12
]}

机构：

[1] China Med Univ, Grad Inst Basic Med Sci, Taichung, Taiwan

[2] Taichung Vet Gen Hosp, Puli Branch, Nantou, Taiwan

[3] China Med Univ, Beigang Hosp, Chinese Med Dept, Yunlin, Taiwan

[4] Mackay Mem Hosp, Div Colorectal Surg, Taipei, Taiwan

[5] Nursing & Management Coll, Mackay Jr Coll Med, Taipei, Taiwan

[6] Univ Taipei, Dept Sports Sci, Taipei, Taiwan

[7] China Med Univ, Dept Biol Sci & Technol, Taichung, Taiwan

[8] Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan

[9] Jen Teh Jr Coll Med, Dept Med Technol, Miaoli, Taiwan

[10] China Med Univ, Grad Inst Chinese Med Sci, Taichung, Taiwan

[11] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan

[12] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan

来源：

CANCER LETTERS | 2014年 / 349卷 / 01期

关键词：

Chemoresistance; CPT-11; NF-kappa B; Metastasis; Autophagy; COLORECTAL-CANCER; INDUCIBLE CHEMORESISTANCE; ANTICANCER DRUGS; GEFITINIB IRESSA; INHIBITION; CHEMOTHERAPY; MECHANISMS; THERAPY; DEATH; 5-FLUOROURACIL;

D O I：

10.1016/j.canlet.2014.03.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapy is usually applied to treat colon cancer but leads to chemoresistance, and increased metastasis and invasion. The main focus of this study is to observe effects of resistance to irinotecan (CPT-11) on metastasis, invasion and autophagy in CPT-11 resistant (CPT-11-R) LoVo colon cancer cells. CPT-11, a topoisomerase I inhibitor and a first-line chemotherapeutic drug, is used to treat colon cancer. CPT-11-R cells were constructed in a step-wise fashion with increasing CPT-11 doses. The CPT-11-R strain had a significantly lower expression of Wnt/beta-catenin pathway, but induced an EGFR/IKK alpha/beta/NF-kappa B pathway with elevated cell cycle, metastasis and basal autophagy. C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：51 / 60

页数：10

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