DNA-selective hybridization and dual strand invasion of short double-stranded DNA using pyren-1-ylcarbonyl-functionalized 4′-C-piperazinomethyl-DNA

被引：41

作者：

Bryld, T ^{[1
]}

Hojland, T ^{[1
]}

Wengel, J ^{[1
]}

机构：

[1] Univ So Denmark, Dept Chem, Nucl Acid Ctr, DK-5230 Odense M, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 09期

关键词：

D O I：

10.1039/b402414a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Incorporation of a novel pyren-1-ylcarbonyl-functionalized 4'-C-piperazinomethyl-DNA monomer into oligodeoxynucleotides leads to increased thermal stability of duplexes with DNA complements but reduced thermal stability of duplexes with RNA complements. This DNA-selective hybridization is explored for recognition of double-stranded DNA by a novel dual strand invasion approach.

引用

页码：1064 / 1065

页数：2

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