Latest developments in molecular tracers for fluorescence image-guided cancer surgery

被引：375

作者：

Hernot, Sophie ^{[1
]}

van Manen, Labrinus ^{[2
]}

Debie, Pieterjan ^{[1
]}

Mieog, Jan Sven David ^{[2
]}

Vahrmeijer, Alexander Lucas ^{[2
]}

机构：

[1] Vrije Univ Brussel, Lab In Vivo Cellular & Mol Imaging, Laarbeeklaan 103, B-1090 Brussels, Belgium

[2] Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands

来源：

LANCET ONCOLOGY | 2019年 / 20卷 / 07期

关键词：

INTRAOPERATIVE DETECTION; 5-AMINOLEVULINIC ACID; SURGICAL NAVIGATION; REAL-TIME; RESECTION; IDENTIFICATION; DISEASE; SAFETY; HEAD; CETUXIMAB-IRDYE800CW;

D O I：

10.1016/S1470-2045(19)30317-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Real-time intraoperative guidance is essential during oncological surgery for complete and safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown potential for guiding surgeons during complex interventions. Recently, there has been a shift towards the use of fluorescence contrast agents for molecular imaging. The first targeted fluorescent agents, of which most consist of approved therapeutic antibodies conjugated to a fluorescent dye, have been evaluated in several early-phase clinical trials. Moreover, advances in protein engineering and drug design have led to the development of a variety of tracers suitable for molecular fluorescence image-guided surgery. In this Review, we discuss preclinical and clinical evidence, ongoing clinical trials, and the latest developments in the field of molecular near-infrared tracers for fluorescence-guided cancer surgery.

引用

页码：E354 / E367

页数：14

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