IDH Mutation, Competitive Inhibition of FTO, and RNA Methylation

被引:68
作者
Elkashef, Sara M. [1 ]
Lin, An-Ping [1 ]
Myers, Jamie [1 ]
Sill, Heinz [2 ]
Jiang, Daifeng [1 ]
Dahia, Patricia L. M. [1 ,3 ]
Aguiar, Ricardo C. T. [1 ,3 ,4 ]
机构
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Hematol & Med Oncol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA
[2] Med Univ Graz, Div Hematol, A-8036 Graz, Austria
[3] Univ Texas Hlth Sci Ctr San Antonio, Greehey Childrens Canc Res Inst, San Antonio, TX 78229 USA
[4] South Texas Vet Hlth Care Syst, Audie Murphy VA Hosp, San Antonio, TX 78229 USA
关键词
D O I
10.1016/j.ccell.2017.04.001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:619 / 620
页数:2
相关论文
共 5 条
  • [1] Oncogenic Isocitrate Dehydrogenase Mutations: Mechanisms, Models, and Clinical Opportunities
    Cairns, Rob A.
    Mak, Tak W.
    [J]. CANCER DISCOVERY, 2013, 3 (07) : 730 - 741
  • [2] The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond
    Fedeles, Bogdan I.
    Singh, Vipender
    Delaney, James C.
    Li, Deyu
    Essigmann, John M.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (34) : 20734 - 20742
  • [3] Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation
    Garrett-Bakelman, Francine E.
    Melnick, Ari M.
    [J]. EPIGENOMICS, 2016, 8 (07) : 945 - 957
  • [4] FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase
    Li, Zejuan
    Weng, Hengyou
    Su, Rui
    Weng, Xiaocheng
    Zuo, Zhixiang
    Li, Chenying
    Huang, Huilin
    Nachtergaele, Sigrid
    Dong, Lei
    Hu, Chao
    Qin, Xi
    Tang, Lichun
    Wang, Yungui
    Hong, Gia-Ming
    Huang, Hao
    Wang, Xiao
    Chen, Ping
    Gurbuxani, Sandeep
    Arnovitz, Stephen
    Li, Yuanyuan
    Li, Shenglai
    Strong, Jennifer
    Neilly, Mary Beth
    Larson, Richard A.
    Jiang, Xi
    Zhang, Pumin
    Jin, Jie
    He, Chuan
    Chen, Jianjun
    [J]. CANCER CELL, 2017, 31 (01) : 127 - 141
  • [5] D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2
    Lin, An-Ping
    Abbas, Saman
    Kim, Sang-Woo
    Ortega, Manoela
    Bouamar, Hakim
    Escobedo, Yissela
    Varadarajan, Prakash
    Qin, Yuejuan
    Sudderth, Jessica
    Schulz, Eduard
    Deutsch, Alexander
    Mohan, Sumitra
    Ulz, Peter
    Neumeister, Peter
    Rakheja, Dinesh
    Gao, Xiaoli
    Hinck, Andrew
    Weintraub, Susan T.
    DeBerardinis, Ralph J.
    Sill, Heinz
    Dahia, Patricia L. M.
    Aguiar, Ricardo C. T.
    [J]. NATURE COMMUNICATIONS, 2015, 6