Synthesis and Antibacterial Activity of a Novel Class of Benzylidenrhodanine Based Furan Derivatives

被引：4

作者：

Baharfar, Robabeh ^{[1
]}

Peiman, Sahar ^{[1
]}

Mohseni, Mojtaba ^{[2
]}

机构：

[1] Univ Mazandaran, Fac Chem, Dept Organ Chem, Babol Sar, Iran

[2] Univ Mazandaran, Fac Sci, Dept Mol & Cell Biol, Babol Sar, Iran

来源：

LETTERS IN ORGANIC CHEMISTRY | 2014年 / 11卷 / 06期

关键词：

Antibacterial activity; Benzylidenrhodanine; Dialkyl acetylenedicarboxylates; tert-butyl isocyanide; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; RHODANINE DERIVATIVES; INHIBITORS; IDENTIFICATION; KETENIMINES; ISOCYANIDES; HIV-1;

D O I：

10.2174/1570178611666140218004601

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple synthesis of novel benzylidenrhodanine based Furan derivatives was described from 5-arylidene 3-carboxymethylrhodanine derivatives via multi-component reactions. The reactive 1:1 intermediate produced from the reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates was trapped at room temperature by 5-arylidene 3-carboxymethylrhodanine derivatives to yield polyfunctionalized furan rings in fairly good yields. The products have been analyzed for antibacterial activity against Gram positive and Gram negative bacteria. The results indicated that the synthesized compounds are effective against bacterial growth retardation activity to some extent and their effectiveness is higher for Staphylococcusaureus.

引用

页码：393 / 397

页数：5

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