Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax

被引：115

作者：

Fang, Xiaodong ^{[1
,2
]}

Nevo, Eviatar ^{[3
]}

Han, Lijuan ^{[1
]}

Levanon, Erez Y. ^{[4
]}

Zhao, Jing ^{[2
,5
]}

Avivi, Aaron ^{[3
]}

Larkin, Denis ^{[6
]}

Jiang, Xuanting ^{[1
]}

Feranchuk, Sergey ^{[7
]}

Zhu, Yabing ^{[1
]}

Fishman, Alla ^{[7
]}

Feng, Yue ^{[1
]}

Sher, Noa ^{[7
]}

Xiong, Zhiqiang ^{[1
]}

Hankeln, Thomas ^{[8
]}

Huang, Zhiyong ^{[1
]}

Gorbunova, Vera ^{[9
]}

Zhang, Lu ^{[1
,10
]}

Zhao, Wei ^{[1
]}

Wildman, Derek E. ^{[11
]}

Xiong, Yingqi ^{[5
]}

Gudkov, Andrei ^{[12
]}

Zheng, Qiumei ^{[5
]}

Rechavi, Gideon ^{[13
,14
,15
]}

Liu, Sanyang ^{[1
]}

Bazak, Lily ^{[4
]}

Chen, Jie ^{[1
]}

Knisbacher, Binyamin A. ^{[4
]}

Lu, Yao ^{[1
]}

Shams, Imad ^{[3
]}

Gajda, Krzysztof ^{[6
]}

Farre, Marta ^{[6
]}

Kim, Jaebum ^{[16
]}

Lewin, Harris A. ^{[17
]}

Ma, Jian ^{[18
,19
]}

Band, Mark ^{[20
]}

Bicker, Anne ^{[8
]}

Kranz, Angela ^{[8
]}

Mattheus, Tobias ^{[8
]}

Schmidt, Hanno ^{[8
]}

Seluanov, Andrei ^{[9
]}

Azpurua, Jorge ^{[9
]}

McGowen, Michael R. ^{[11
]}

Ben Jacob, Eshel ^{[21
]}

Li, Kexin ^{[3
]}

Peng, Shaoliang ^{[22
,23
]}

Zhu, Xiaoqian ^{[22
,23
]}

Liao, Xiangke ^{[22
,23
]}

Li, Shuaicheng ^{[10
]}

Krogh, Anders ^{[2
]}

机构：

[1] BGI Shenzhen, BGI Tech, Shenzhen 518083, Peoples R China

[2] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen N, Denmark

[3] Univ Haifa, Inst Evolut, IL-31905 Haifa, Israel

[4] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-5290002 Ramat Gan, Israel

[5] BGI Shenzhen, China Natl GeneBank, Shenzhen 518083, Peoples R China

[6] Aberystwyth Univ, Inst Biol Environm & Rural Sci, Aberystwyth SY23 3DA, Dyfed, Wales

[7] Univ Haifa, Tauber Bioinformat Res Ctr, IL-31905 Haifa, Israel

[8] Johannes Gutenberg Univ Mainz, Inst Mol Genet, D-55099 Mainz, Germany

[9] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

[10] City Univ Hong Kong, Dept Comp Sci, Kowloon, Hong Kong, Peoples R China

[11] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA

[12] Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY 14263 USA

[13] Chaim Sheba Med Ctr, Edmond & Lily Safra Childrens Hosp, Div Pediat Hematol & Oncol, IL-52662 Tel Hashomer, Israel

[14] Chaim Sheba Med Ctr, Sheba Canc Res Ctr, IL-52662 Tel Hashomer, Israel

[15] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

[16] Konkuk Univ, Dept Anim Biotechnol, Seoul 143701, South Korea

[17] Univ Calif Davis, Dept Ecol & Evolut, Davis, CA 95616 USA

[18] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA

[19] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA

[20] Univ Illinois, Roy J Carver Biotechnol Ctr, Urbana, IL 61801 USA

[21] Tel Aviv Univ, Sch Phys & Astron, Maguy Glass Chair Phys Complex Syst, IL-69978 Tel Aviv, Israel

[22] Natl Univ Def Technol, Sch Comp Sci, Changsha 410073, Peoples R China

[23] Natl Univ Def Technol, State Key Lab High Performance Comp, Changsha 410073, Peoples R China

[24] Univ Haifa, Dept Evolutionary & Environm Biol, IL-31905 Haifa, Israel

[25] King Abdulaziz Univ, Princess Al Jawhara Ctr Excellence Res Hereditary, Jeddah 21441, Saudi Arabia

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

美国国家科学基金会; 中国国家自然科学基金; 英国生物技术与生命科学研究理事会;

关键词：

IN-VIVO; CANCER RESISTANCE; SKELETAL-MUSCLES; HARDERIAN-GLAND; CIRCADIAN GENES; HEAT-SHOCK; EHRENBERGI; HYPOXIA; EXPRESSION; EVOLUTION;

D O I：

10.1038/ncomms4966

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The blind mole rat (BMR), Spalax galili, is an excellent model for studying mammalian adaptation to life underground and medical applications. The BMR spends its entire life underground, protecting itself from predators and climatic fluctuations while challenging it with multiple stressors such as darkness, hypoxia, hypercapnia, energetics and high pathonecity. Here we sequence and analyse the BMR genome and transcriptome, highlighting the possible genomic adaptive responses to the underground stressors. Our results show high rates of RNA/DNA editing, reduced chromosome rearrangements, an over-representation of short interspersed elements (SINEs) probably linked to hypoxia tolerance, degeneration of vision and progression of photoperiodic perception, tolerance to hypercapnia and hypoxia and resistance to cancer. The remarkable traits of the BMR, together with its genomic and transcriptomic information, enhance our understanding of adaptation to extreme environments and will enable the utilization of BMR models for biomedical research in the fight against cancer, stroke and cardiovascular diseases.

引用

页数：9

共 70 条

[1] The SINE-encoded mouse B2 RNA represses mRNA transcription in response to heat shock
Allen, TA
Von Kaenel, S
Goodrich, JA
Kugel, JF
[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (09) : 816 - 821
[2] BLOOD CAPILLARY DENSITY IN HEART AND SKELETAL-MUSCLES OF THE FOSSORIAL MOLE RAT
ARIELI, R
AR, A
[J]. PHYSIOLOGICAL ZOOLOGY, 1981, 54 (01): : 22 - 27
[3] ADAPTIVE RESPIRATORY VARIATION IN 4 CHROMOSOMAL SPECIES OF MOLE RATS
ARIELI, R
ARIELI, M
HETH, G
NEVO, E
[J]. EXPERIENTIA, 1984, 40 (05): : 512 - 514
[4] HEMATOCRIT AND HEMOGLOBIN CONCENTRATION IN 4 CHROMOSOMAL SPECIES AND SOME ISOLATED POPULATIONS OF ACTIVELY SPECIATING SUBTERRANEAN MOLE RATS IN ISRAEL
ARIELI, R
HETH, G
NEVO, E
HOCH, D
[J]. EXPERIENTIA, 1986, 42 (04): : 441 - 443
[5] ADAPTIVE HEART AND BREATHING FREQUENCIES IN 4 ECOLOGICALLY DIFFERENTIATING CHROMOSOMAL SPECIES OF MOLE RATS IN ISRAEL
ARIELI, R
HETH, G
NEVO, E
ZAMIR, Y
NEUTRA, O
[J]. EXPERIENTIA, 1986, 42 (02): : 131 - 133
[6] Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation
Ashur-Fabian, C
Avivi, A
Trakhtenbrot, L
Adamsky, K
Cohen, M
Kajakaro, G
Joel, A
Amariglio, N
Nevo, E
Rechavi, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (33) : 12236 - 12241
[7] p53 - A key player in tumoral and evolutionary adaptation - A lesson from the Israeli blind subterranean mole rat
Avivi, A
Ashur-Fabian, O
Amariglio, N
Nevo, E
Rechavi, G
[J]. CELL CYCLE, 2005, 4 (03) : 368 - 372
[8] Circadian genes in a blind subterranean mammal III:: Molecular cloning and circadian regulation of cryptochrome genes in the blind subterranean mole rat, Spalax ehrenbergi superspecies
Avivi, A
Oster, H
Joel, A
Beiles, A
Albrecht, U
Nevo, E
[J]. JOURNAL OF BIOLOGICAL RHYTHMS, 2004, 19 (01) : 22 - 34
[9] Circadian genes in a blind subterranean mammal II:: Conservation and uniqueness of the three Period homologs in the blind subterranean mole rat, Spalax ehrenbergi superspecies
Avivi, A
Oster, H
Joel, A
Beiles, A
Albrecht, U
Nevo, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) : 11718 - 11723
[10] Biological clock in total darkness:: The Clock/MOP3 circadian system of the blind subterranean mole rat
Avivi, A
Albrecht, U
Oster, H
Joel, A
Beiles, A
Nevo, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) : 13751 - 13756

← 1 2 3 4 5 6 7 →