Association of Megsin 2093C/T, 2180C/T and C25663G gene polymorphism with the risk of IgA nephropathy

被引：3

作者：

Mao, Song ^{[1
]}

Ren, Xianguo ^{[2
]}

Huang, Songming ^{[1
]}

Zhang, Aihua ^{[1
]}

机构：

[1] Nanjing Med Univ, Nanjing Childrens Hosp, Dept Nephrol, Nanjing 210008, Jiangsu, Peoples R China

[2] Nanjing Jinling Hosp, Res Inst Nephrol, Nanjing, Jiangsu, Peoples R China

来源：

RENAL FAILURE | 2014年 / 36卷 / 05期

基金：

中国国家自然科学基金;

关键词：

2093C/T; 2180C/T; C25663G; gene polymorphisms; IgA nephropathy; meta-analysis; IMMUNOGLOBULIN-A NEPHROPATHY; DIABETIC-NEPHROPATHY; TRANSGENIC MICE; SERPIN; ANGIOTENSINOGEN; OVEREXPRESSION; HYPERTENSION; PROGRESSION; REGION; MODEL;

D O I：

10.3109/0886022X.2014.890058

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The association between megsin 2093C/T, 2180C/T and C25663G gene polymorphisms and IgA nephropathy (IgAN) risk remains unclear. We aimed to evaluate the association between megsin 2093C/T, 2180C/T and C25663G gene polymorphisms and IgAN risk by performing a meta-analysis. Eligible studies were searched according to predefined criteria by using electronic databases. Six articles were identified for the analysis of the association between megsin 2093C/T, 2180C/T and C25663G gene polymorphisms and IgAN risk. 2093C/T C allele was associated with IgAN risk in overall populations and Asians (overall populations: p = 0.014, Asians: p = 0.037). 2093C/T CC/TT genotype was not associated with IgAN risk in overall populations, Caucasians and Asians. 2180C/T C allele was correlated with IgAN risk in Caucasians (p = 0.024). 2180C/T CC/TT genotype was not associated with IgAN risk in overall populations, Caucasians and Asians. C25663G gene polymorphism was not associated with IgAN onset in Asians. In conclusion, megsin 2093C/T C allele may be genetic marker for IgAN susceptibility in overall populations and Asians. 2180C/T C allele may be risk factor for IgAN onset in Caucasians. However, more studies should be performed in the future.

引用

页码：817 / 822

页数：6

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