Association Between Alzheimer Disease and the-491T Allele of Regulatory Region Polymorphism of Apolipoprotein E in a Tunisian Population

被引：4

作者：

Achouri-Rassas, Afef ^{[1
,2
]}

Fredj, Sondes Hadj ^{[2
]}

Khiari, Hela Mrabet ^{[1
]}

Bibi, Amina ^{[2
]}

Siala, Hajer ^{[2
]}

Mrabet, Amel ^{[1
]}

Messaoud, Taieb ^{[2
]}

机构：

[1] Charles Nicolle Hosp, Dept Neurol, Tunis 1006, Tunisia

[2] Childrens Hosp, Biochem & Mol Biol Lab, Tunis 1029, Tunisia

来源：

NEUROCHEMICAL RESEARCH | 2014年 / 39卷 / 02期

关键词：

Alzheimer disease; Apolipoprotein E; -491A/T polymorphism; Risk factor; E PROMOTER POLYMORPHISMS; APOE PROMOTER; E GENE; RISK-FACTOR; -491A/T;

D O I：

10.1007/s11064-013-1213-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The apolipoprotein E (APOE) is a well-established risk factor for late-onset Alzheimer's disease (AD). Several studies have attempted to confirm the association between the polymorphism located at position -491 in the transcriptional regulatory region of the APOE gene and AD. We examined in 85 AD patients and 90 control subjects of a Tunisian population the potential involvement of this polymorphism as a risk factor for AD, either through an independent effect or through interaction with the existing APOE epsilon 4 allele risk. The T allele frequency was significantly higher in the AD patients group (45.3 %) than in the controls group (32.78 %) and may possibly constitute a significant risk factor for AD. The APOE epsilon 4 allele did not influence the distribution of the -491 polymorphism after stratification.

引用

页码：244 / 247

页数：4

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