Nickel-Catalyzed Coupling of Fluoroarenes and Amines

被引：30
作者：
Zhu, Feng [1 ,2 ]
Wang, Zhong-Xia [1 ,2 ]
机构：
[1] Univ Sci & Technol China, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 18期
基金：
中国国家自然科学基金;
关键词：
catalysis; CF bond activation; coupling; fluoroarenes; nickel; AROMATIC-SUBSTITUTION REACTIONS; F BOND ACTIVATION; ARYL HALIDES; N-ARYLATION; HETEROCYCLIC CARBENE; AMINATION REACTIONS; COMPLEXES; CHLORIDES; REDUCTION; PYRIDINES;
D O I：
10.1002/adsc.201300485
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The combination of bis(cyclooctadiene)nickel [Ni(COD)(2)] and 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride (IPrHCl) effectively catalyzes coupling of fluoroarenes with amines in the presence of sodium tert-butoxide (t-BuONa). Activated, unactivated and deactivated fluoroarenes as well as fluoropyridines can react with cyclic or acyclic aliphatic amines. The reactions tolerate various functional groups in the fluorides including PhC(O), C(O)NEt2, CF3, OMe and vinyl groups.
引用
收藏
页码：3694 / 3702
页数：9
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