Amyloid load and cerebral atrophy in Alzheimer's disease:: An 11C-PIB positron emission tomography study

被引：148

作者：

Archer, Hilary A.

Edison, Paul

Brooks, David J.

Barnes, Jo

Frost, Chris

Yeatman, Toni

Fox, Nick C.

Rossor, Martin N.

机构：

[1] Nalt Hosp Neurol & Neurosurg, Inst Neurol, Dementia Res Ctr, London WC10 3BG, England

[2] Hammersmith Hosp, Imperial Coll London, Cyclotron Unit, Med Res Ctr Clin Sci, London, England

[3] Univ London London Sch Hyg & Trop Med, Med Stat Unit, London WC1E 7HT, England

来源：

ANNALS OF NEUROLOGY | 2006年 / 60卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1002/ana.20889

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. C-11-PIB(C-11-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional C-11-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.

引用

收藏

页码：145 / 147

页数：3

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