pH sensitive nanocomposite hydrogel beads based on carboxymethyl cellulose/layered double hydroxide as drug delivery systems

被引：139
作者：
Barkhordari, Soroush [1 ]
Yadollahi, Mehdi [1 ]
Namazi, Hassan [1 ]
机构：
[1] Univ Tabriz, Res Lab Dendrimers & Nanopolymers, Fac Chem, Tabriz, Iran
来源：
JOURNAL OF POLYMER RESEARCH | 2014年 / 21卷 / 06期
关键词：
Layered double hydroxides (LDH); Carboxymethyl cellulose; Nanocomposite; Hydrogel; Drug delivery systems; pH sensitivity; LAYERED DOUBLE HYDROXIDES; IN-VITRO RELEASE; HYBRID BEADS; INTERCALATION; SODIUM; CHITOSAN; BEHAVIOR; ACIDS; GELS; GUM;
D O I：
10.1007/s10965-014-0454-z
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In this paper new pH sensitive nanocomposite beads were prepared by the combination of layered double hydroxides (LDH) and carboxymethyl cellulose (CMC). Ibuprofen (IBU), as a model drug, was intercalated between LDH layers through the co-precipitation method. The synthesized LDH-IBU nanohybrids and nanocomposites beads were characterized using FTIR, XRD, and SEM. In vitro tests of drug delivery in conditions simulating the gastrointestinal tract were carried out to prove the effectiveness of this novel type of nanocomposite beads as a controlled drug delivery system (DDS). The drug release tests revealed a better protection against stomach pH and a controlled liberation in the intestinal tract conditions for new nanocomposite beads.
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页数：9
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