pH sensitive nanocomposite hydrogel beads based on carboxymethyl cellulose/layered double hydroxide as drug delivery systems

被引：140

作者：

Barkhordari, Soroush ^{[1
]}

Yadollahi, Mehdi ^{[1
]}

Namazi, Hassan ^{[1
]}

机构：

[1] Univ Tabriz, Res Lab Dendrimers & Nanopolymers, Fac Chem, Tabriz, Iran

来源：

JOURNAL OF POLYMER RESEARCH | 2014年 / 21卷 / 06期

关键词：

Layered double hydroxides (LDH); Carboxymethyl cellulose; Nanocomposite; Hydrogel; Drug delivery systems; pH sensitivity; LAYERED DOUBLE HYDROXIDES; IN-VITRO RELEASE; HYBRID BEADS; INTERCALATION; SODIUM; CHITOSAN; BEHAVIOR; ACIDS; GELS; GUM;

D O I：

10.1007/s10965-014-0454-z

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this paper new pH sensitive nanocomposite beads were prepared by the combination of layered double hydroxides (LDH) and carboxymethyl cellulose (CMC). Ibuprofen (IBU), as a model drug, was intercalated between LDH layers through the co-precipitation method. The synthesized LDH-IBU nanohybrids and nanocomposites beads were characterized using FTIR, XRD, and SEM. In vitro tests of drug delivery in conditions simulating the gastrointestinal tract were carried out to prove the effectiveness of this novel type of nanocomposite beads as a controlled drug delivery system (DDS). The drug release tests revealed a better protection against stomach pH and a controlled liberation in the intestinal tract conditions for new nanocomposite beads.

引用

页数：9

共 53 条

[1] Intercalation of amino acids and oligopeptides into Zn-Al layered double hydroxide by coprecipitation reaction [J].

Aisawa, Sumio ;

Sasaki, Shuji ;

Takahashi, Satoshi ;

Hirahara, Hidetoshi ;

Nakayama, Hirokazu ;

Narita, Eiichi .

JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS, 2006, 67 (5-6) :920-925

[2] Bionanocomposites based on alginate-zein/layered double hydroxide materials as drug delivery systems [J].

Alcantara, A. C. S. ;

Aranda, P. ;

Darder, M. ;

Ruiz-Hitzky, E. .

JOURNAL OF MATERIALS CHEMISTRY, 2010, 20 (42) :9495-9504

[3] Eudragit® and hydrotalcite-like anionic clay composite system for diclofenac colonic delivery [J].

Ambrogi, V. ;

Perioli, L. ;

Ricci, M. ;

Pulcini, L. ;

Nocchetti, M. ;

Giovagnoli, S. ;

Rossi, C. .

MICROPOROUS AND MESOPOROUS MATERIALS, 2008, 115 (03) :405-415

[4] Intercalation compounds of hydrotalcite-like anionic clays with antiinflammatory agents - I. Intercalation and in vitro release of ibuprofen [J].

Ambrogi, V ;

Fardella, G ;

Grandolini, G ;

Perioli, L .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 220 (1-2) :23-32

[5] Novel composite blend microbeads of sodium alginate coated with chitosan for controlled release of amoxicillin [J].

Angadi, Sudha C. ;

Manjeshwar, Lata S. ;

Aminabhavi, Tejraj M. .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2012, 51 (1-2) :45-55

[6] Chitosan-based drug delivery systems [J].

Bernkop-Schnuerch, Andreas ;

Duennhaupt, Sarah .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2012, 81 (03) :463-469

[7] Tailored IPN Hydrogel Bead of Sodium Carboxymethyl Cellulose and Sodium Carboxymethyl Xanthan Gum for Controlled Delivery of Diclofenac Sodium [J].

Bhattacharya, Shiv Sankar ;

Shukla, Seema ;

Banerjee, Subham ;

Chowdhury, Purojit ;

Chakraborty, Prithviraj ;

Ghosh, Amitava .

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING, 2013, 52 (08) :795-805

[8] Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug [J].

Boppana, Rashmi ;

Kulkarni, Raghavendra V. ;

Mutalik, Srinivas S. ;

Setty, C. Mallikarjun ;

Sa, Biswanath .

JOURNAL OF MICROENCAPSULATION, 2010, 27 (04) :337-344

[9] The intercalation of carboxylic acids into layered double hydroxides: A critical evaluation and review of the different methods [J].

Carlino, S .

SOLID STATE IONICS, 1997, 98 (1-2) :73-84

[10] Clay minerals and layered double hydroxides for novel biological applications [J].

Choy, Jin-Ho ;

Choi, Soo-Jin ;

Oh, Jae-Min ;

Park, Taeun .

APPLIED CLAY SCIENCE, 2007, 36 (1-3) :122-132

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