Synthesis of novel pyridazine derivatives as potential antimicrobial agents

被引：21

作者：

Behalo, Mohamed S. ^{[1
]}

El-Karim, Iman A. Gad ^{[1
]}

Issac, Yvette A. ^{[1
]}

Farag, Mohamed A. ^{[1
]}

机构：

[1] Benha Univ, Fac Sci, Dept Chem, Banha 13518, Egypt

来源：

JOURNAL OF SULFUR CHEMISTRY | 2014年 / 35卷 / 06期

关键词：

pyridazine; isothiocyanate; triazole; thiazolidine; antimicrobial activity; ARYL ISOTHIOCYANATES; ACID; ANTIBACTERIAL; CHLORIDE;

D O I：

10.1080/17415993.2014.950661

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel pyridazine derivatives incorporated with triazole, thiazolidine, imidazolidine, oxazine, and quinazoline moieties was synthesized by the reaction of [6-(4-phenoxyphenyl) pyridazin-3- yloxy] acetyl isothiocyanate with variety of nucleophilic reagents. The structures of all products were confirmed and characterized by the elemental analysis and spectroscopic studies (IR, MS, H-1 NMR). Also, the products were investigated for their antibacterial and antifungal activities and were compared with the standard drugs. Most of the synthesized compounds demonstrated potent to weak antimicrobial activity. [GRAPHICS] .

引用

页码：661 / 673

页数：13

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