Synthesis of novel pyridazine derivatives as potential antimicrobial agents

被引：21

作者：

Behalo, Mohamed S. ^{[1
]}

El-Karim, Iman A. Gad ^{[1
]}

Issac, Yvette A. ^{[1
]}

Farag, Mohamed A. ^{[1
]}

机构：

[1] Benha Univ, Fac Sci, Dept Chem, Banha 13518, Egypt

来源：

JOURNAL OF SULFUR CHEMISTRY | 2014年 / 35卷 / 06期

关键词：

pyridazine; isothiocyanate; triazole; thiazolidine; antimicrobial activity; ARYL ISOTHIOCYANATES; ACID; ANTIBACTERIAL; CHLORIDE;

D O I：

10.1080/17415993.2014.950661

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel pyridazine derivatives incorporated with triazole, thiazolidine, imidazolidine, oxazine, and quinazoline moieties was synthesized by the reaction of [6-(4-phenoxyphenyl) pyridazin-3- yloxy] acetyl isothiocyanate with variety of nucleophilic reagents. The structures of all products were confirmed and characterized by the elemental analysis and spectroscopic studies (IR, MS, H-1 NMR). Also, the products were investigated for their antibacterial and antifungal activities and were compared with the standard drugs. Most of the synthesized compounds demonstrated potent to weak antimicrobial activity. [GRAPHICS] .

引用

页码：661 / 673

页数：13

共 29 条

[11] Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis [J].

Higdon, Jane V. ;

Delage, Barbara ;

Williams, David E. ;

Dashwood, Roderick H. .

PHARMACOLOGICAL RESEARCH, 2007, 55 (03) :224-236

[12]

Ioannides O, 2010, OPEN NUTRACEUTICALS, V3, P55

[13]

Issac Y.A., 2002, SULFUR LETT, V25, P183, DOI 10.1080/02786110213977

[14]

ISSAC YA, 2008, OLAJ SZAPPAN KOZMETI, V57, P128

[15] Antimicrobial Efficacy of Benzyl Isothiocyanate [J].

Kamii, Eri ;

Isshiki, Kenji .

JOURNAL OF THE FOOD HYGIENIC SOCIETY OF JAPAN, 2009, 50 (06) :311-314

[16] Novel pyridazine derivatives: Synthesis and antimicrobial activity evaluation [J].

Kandile, N. G. ;

Mohamed, M. I. ;

Zaky, H. ;

Mohamed, H. M. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (05) :1989-1996

[17] ADDITION-CYCLIZATIONS OF ETHOXYCARBONYL ISOTHIOCYANATE WITH HYDRAZINE DERIVATIVES AS A SOURCE OF THIADIAZOLES AND TRIAZOLES [J].

KURZER, F ;

SECKER, JL .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1989, 26 (02) :355-360

[18] ANTIBIOTIC PRODUCTION AND BIOCONTROL ACTIVITY BY BACILLUS-SUBTILIS CL27 AND BACILLUS-PUMILUS CL45 [J].

LEIFERT, C ;

LI, H ;

CHIDBUREE, S ;

HAMPSON, S ;

WORKMAN, S ;

SIGEE, D ;

EPTON, HAS ;

HARBOUR, A .

JOURNAL OF APPLIED BACTERIOLOGY, 1995, 78 (02) :97-108

[19] HERSTELLUNG VON ARYL-ISOTHIOCYANATEN AUS ARYLAMINEN UND BIS-DIATHYLTHIOCARBAMOYLSULFIDEN [J].

MARQUARDT, FH .

HELVETICA CHIMICA ACTA, 1966, 49 (05) :1716-+

[20] Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors [J].

Miyamoto, Naoki ;

Oguro, Yuya ;

Takagi, Terufumi ;

Iwata, Hidehisa ;

Miki, Hiroshi ;

Hori, Akira ;

Imamura, Shinichi .

BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (24) :7051-7058

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