Effect of β-cyclodextrin complexation on the photochemical and photosensitizing properties of tolmetin:: A steady-state and time-resolved study

被引：0
|
作者：
Sortino, S
Scaiano, JC
De Guidi, G
Monti, S
机构：
[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy
[2] Univ Ottawa, Dept Chem, Ottawa, ON, Canada
[3] CNR, Ist Fotochim & Radiaz Alta Energia, Area Ric, I-40126 Bologna, Italy
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1999年 / 70卷 / 04期
关键词：
D O I：
10.1562/0031-8655(1999)070<0549:EOCCOT>2.3.CO;2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of P-cyclodextrin complexation on the photochemical and photosensitizing properties of tolmetin have been investigated. Absorption, emission, circular dichroism and NMR measurements were used to characterize the host-guest complex. Nanosecond laser flash photolysis and steady-state photolysis experiments were performed to clarify the photoreactivity of the drug in the macrocycle. The decarboxylation of the drug is markedly reduced upon inclusion and the rate constants of the decay of the transient intermediates involved in tolmetin photodecomposition were slowed down due to their incorporation in the hydrophobic cavity. This also influenced the distribution of the stable photoproducts. A remarkable cyclodextrin-mediated protection against the tolmetin-photoinduced damage on biological substrates was observed. A rationale for these biological effects is provided.
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页码：549 / 556
页数：8
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