Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy

被引:17
作者
Salvio, Gianmaria [1 ]
Ciarloni, Alessandro [1 ]
Cutini, Melissa [1 ]
delli Muti, Nicola [1 ]
Finocchi, Federica [1 ]
Perrone, Michele [1 ]
Rossi, Silvia [1 ]
Balercia, Giancarlo [1 ]
机构
[1] Polytech Univ Marche, Dept Clin & Mol Sci DISCLIMO, Div Endocrinol, I-60126 Ancona, Italy
关键词
couple infertility; sterility; sperm quality; abnormal semen analysis; overweight; obesity; visceral fat; cardiovascular risk; C-REACTIVE PROTEIN; OXIDATIVE STRESS; INSULIN-RESISTANCE; LIFE-STYLE; REPRODUCTIVE FUNCTION; LIPID-PEROXIDATION; DIABETES-MELLITUS; HUMAN SPERMATOZOA; SEMEN PARAMETERS; SPERM FUNCTION;
D O I
10.3390/ijms23105497
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and atherogenic dyslipidemia, which lead to premature morbidity and mortality due to cardiovascular disease (CVD). Male infertility is another common condition which accounts for about 50% of cases of couple infertility worldwide. Interestingly, male infertility and MetS shares several risk factors (e.g., smoking, ageing, physical inactivity, and excessive alcohol consumption), leading to reactive oxygen species (ROS) production and increased oxidative stress (OS), and resulting in endothelial dysfunction and altered semen quality. Thus, the present narrative review aims to discuss the pathophysiological mechanisms which link male infertility and MetS and to investigate the latest available evidence on the reproductive consequences of MetS.
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页数:16
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