Histone lysine demethylases in Drosophila melanogaster

被引：18
作者：
Holowatyj, Andreana [1 ,2 ]
Yang, Zeng-Quan [1 ,2 ]
Pile, Lori A. [2 ,3 ]
机构：
[1] Wayne State Univ, Sch Med, Dept Oncol, Detroit, MI USA
[2] Wayne State Univ, Sch Med, Karmanos Canc Inst, Detroit, MI 48202 USA
[3] Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA
来源：
FLY | 2015年 / 9卷 / 01期
关键词：
chromatin; cancer; demethylase; Drosophila; Epigenetics; histone; JmjC domain; KDM; modifications; tumorigenesis; BREAST-CANCER; GENOMIC AMPLIFICATION; GENETIC SCREEN; H3; METHYLATION; CHROMATIN; TRANSCRIPTION; PROTEIN; NOTCH; JMJC;
D O I：
10.1080/19336934.2015.1074787
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epigenetic regulation of chromatin structure is a fundamental process for eukaryotes. Regulators include DNA methylation, microRNAs and chromatin modifications. Within the chromatin modifiers, one class of enzymes that can functionally bind and modify chromatin, through the removal of methyl marks, is the histone lysine demethylases. Here, we summarize the current findings of the 13 known histone lysine demethylases in Drosophila melanogaster, and discuss the critical role of these histone-modifying enzymes in the maintenance of genomic functions. Additionally, as histone demethylase dysregulation has been identified in cancer, we discuss the advantages for using Drosophila as a model system to study tumorigenesis.
引用
收藏
页码：36 / 44
页数：9
相关论文
共 50 条
  • [41] Lysine Demethylases Inhibitors
    Suzuki, Takayoshi
    Miyata, Naoki
    JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (24) : 8236 - 8250
  • [42] The role of histone H3 lysine demethylases in glioblastoma
    Young, Dejauwne
    Guha, Chandan
    Sidoli, Simone
    CANCER AND METASTASIS REVIEWS, 2023, 42 (02) : 445 - 454
  • [43] Taking Me away: the function of phosphorylation on histone lysine demethylases
    Karakatsanis, Nicola M.
    Hamey, Joshua J.
    Wilkins, Marc R.
    TRENDS IN BIOCHEMICAL SCIENCES, 2024, 49 (03) : 257 - 276
  • [44] Lysine-specific histone demethylases in normal and malignant hematopoiesis
    Andricovich, Jaclyn
    Kai, Yan
    Tzatsos, Alexandros
    EXPERIMENTAL HEMATOLOGY, 2016, 44 (09) : 778 - 782
  • [45] High-throughput screening to identify inhibitors of lysine demethylases
    Gale, Molly
    Yan, Qin
    EPIGENOMICS, 2015, 7 (01) : 57 - 65
  • [46] Functional antagonism between histone H3K4 demethylases in vivo
    Di Stefano, Luisa
    Walker, James A.
    Burgio, Giosalba
    Corona, Davide F. V.
    Mulligan, Peter
    Naeaer, Anders M.
    Dyson, Nicholas J.
    GENES & DEVELOPMENT, 2011, 25 (01) : 17 - 28
  • [47] Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila
    Penke, Taylor J. R.
    McKay, Daniel J.
    Strahl, Brian D.
    Matera, A. Gregory
    Duronio, Robert J.
    GENETICS, 2018, 208 (01) : 229 - 244
  • [48] Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors
    Lohse, Brian
    Nielsen, Anders L.
    Kristensen, Jan B. L.
    Helgstrand, Charlotte
    Cloos, Paul A. C.
    Olsen, Lars
    Gajhede, Michael
    Clausen, Rasmus P.
    Kristensen, Jesper L.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (39) : 9100 - 9103
  • [49] Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery
    Das, Nando Dulal
    Niwa, Hideaki
    Umehara, Takashi
    EPIGENOMES, 2023, 7 (01)
  • [50] Histone H3 lysine 4 methylation recruits DNA demethylases to enforce gene expression in Arabidopsis
    Wang, Ming
    He, Yan
    Zhong, Zhenhui
    Papikian, Ashot
    Wang, Shuya
    Gardiner, Jason
    Ghoshal, Basudev
    Feng, Suhua
    Jami-Alahmadi, Yasaman
    Wohlschlegel, James A.
    Jacobsen, Steven E.
    NATURE PLANTS, 2025, : 206 - 217
12345