Histone lysine demethylases in Drosophila melanogaster

被引：18
作者：
Holowatyj, Andreana [1 ,2 ]
Yang, Zeng-Quan [1 ,2 ]
Pile, Lori A. [2 ,3 ]
机构：
[1] Wayne State Univ, Sch Med, Dept Oncol, Detroit, MI USA
[2] Wayne State Univ, Sch Med, Karmanos Canc Inst, Detroit, MI 48202 USA
[3] Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA
来源：
FLY | 2015年 / 9卷 / 01期
关键词：
chromatin; cancer; demethylase; Drosophila; Epigenetics; histone; JmjC domain; KDM; modifications; tumorigenesis; BREAST-CANCER; GENOMIC AMPLIFICATION; GENETIC SCREEN; H3; METHYLATION; CHROMATIN; TRANSCRIPTION; PROTEIN; NOTCH; JMJC;
D O I：
10.1080/19336934.2015.1074787
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epigenetic regulation of chromatin structure is a fundamental process for eukaryotes. Regulators include DNA methylation, microRNAs and chromatin modifications. Within the chromatin modifiers, one class of enzymes that can functionally bind and modify chromatin, through the removal of methyl marks, is the histone lysine demethylases. Here, we summarize the current findings of the 13 known histone lysine demethylases in Drosophila melanogaster, and discuss the critical role of these histone-modifying enzymes in the maintenance of genomic functions. Additionally, as histone demethylase dysregulation has been identified in cancer, we discuss the advantages for using Drosophila as a model system to study tumorigenesis.
引用
收藏
页码：36 / 44
页数：9
相关论文
共 50 条
  • [31] The emerging role of histone lysine demethylases in prostate cancer
    Francesco Crea
    Lei Sun
    Antonello Mai
    Yan Ting Chiang
    William L Farrar
    Romano Danesi
    Cheryl D Helgason
    Molecular Cancer, 11
  • [32] Histone demethylases in chromatin cross-talks
    Verrier, Laure
    Vandromme, Marie
    Trouche, Didier
    BIOLOGY OF THE CELL, 2011, 103 (08) : 381 - 401
  • [33] Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases
    Niwa, Hideaki
    Umehara, Takashi
    EPIGENETICS, 2017, 12 (05) : 340 - 352
  • [34] Targeting histone lysine methylation in cancer
    McGrath, John
    Trojer, Patrick
    PHARMACOLOGY & THERAPEUTICS, 2015, 150 : 1 - 22
  • [35] Histone lysine methylation: an epigenetic modification?
    Blackledge, Neil P.
    Klose, Robert J.
    EPIGENOMICS, 2010, 2 (01) : 151 - 161
  • [36] The role of histone lysine demethylases in cancer cells' resistance to tyrosine kinase inhibitors
    White, Jasmine Cassar
    Pucci, Perla
    Crea, Francesco
    CANCER DRUG RESISTANCE, 2019, 2 (02) : 326 - 334
  • [37] Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature
    Jeries Abu-Hanna
    Jigisha A. Patel
    Evangelos Anastasakis
    Richard Cohen
    Lucie H. Clapp
    Marilena Loizidou
    Mohammad M. R. Eddama
    Clinical Epigenetics, 2022, 14
  • [38] Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation
    Gazova, Iveta
    Lengeling, Andreas
    Summers, Kim M.
    MOLECULAR GENETICS AND METABOLISM, 2019, 127 (01) : 31 - 44
  • [39] Decoding the histone H4 lysine 20 methylation mark
    Balakrishnan, Lata
    Milavetz, Barry
    CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2010, 45 (05) : 440 - 452
  • [40] The future therapeutic potential of histone demethylases: A critical analysis
    Natoli, Gioacchino
    Testa, Giuseppe
    De Santa, Francesca
    CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2009, 12 (05) : 607 - 615
12345