Sex Differences in Adiposity and Cardiovascular Diseases

被引：28
作者：
Li, Haoyun [1 ]
Konja, Daniels [1 ]
Wang, Luyao [1 ]
Wang, Yu [1 ]
机构：
[1] Univ Hong Kong, Dept Pharmacol & Pharm, State Key Lab Pharmaceut Biotechnol, Hong Kong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 16期
关键词：
obesity; adipose tissue; sexual dimorphism; body fat distribution; cardiovascular diseases; BODY-MASS INDEX; PRESERVED EJECTION FRACTION; CORONARY-HEART-DISEASE; NITRIC-OXIDE SYNTHASE; SARCOPENIC OBESITY; RISK-FACTORS; FAT DISTRIBUTION; HORMONAL CONTRACEPTIVES; INSULIN-RESISTANCE; VISCERAL FAT;
D O I：
10.3390/ijms23169338
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Body fat distribution is a well-established predictor of adverse medical outcomes, independent of overall adiposity. Studying body fat distribution sheds insights into the causes of obesity and provides valuable information about the development of various comorbidities. Compared to total adiposity, body fat distribution is more closely associated with risks of cardiovascular diseases. The present review specifically focuses on the sexual dimorphism in body fat distribution, the biological clues, as well as the genetic traits that are distinct from overall obesity. Understanding the sex determinations on body fat distribution and adiposity will aid in the improvement of the prevention and treatment of cardiovascular diseases (CVD).
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页数：21
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