Clonal Hematopoiesis and risk of Acute Myeloid Leukemia

被引：20

作者：

Desai, Pinkal ^{[1
]}

Hassane, Duane ^{[1
]}

Roboz, Gail J. ^{[1
]}

机构：

[1] Weill Cornell Med, Div Hematol & Oncol, New York, NY USA

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2019年 / 32卷 / 02期

关键词：

Clonal hematopoiesis; CHIP; ARCH; Myelodysplastic syndrome; Acute myeloid leukemia; SHWACHMAN-DIAMOND SYNDROME; FANCONI-ANEMIA PATIENTS; BONE-MARROW FAILURE; SOMATIC MUTATIONS; MYELODYSPLASTIC SYNDROME; PROGNOSTIC RELEVANCE; TP53; MUTATIONS; MALIGNANCIES; EVOLUTION; GENE;

D O I：

10.1016/j.beha.2019.05.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute Myeloid Leukemia, the most common form of acute leukemia in adults, is an aggressive hematopoietic stem cell malignancy that is associated with significant morbidity and mortality. Though AML generally presents de novo, risk factors include exposure to chemotherapy and/or radiation, as well as both familial and acquired bone marrow failure syndromes. Clonal Hematopoiesis (CH) refers to an expansion of blood or marrow cells resulting from somatic mutations in leukemia-associated genes detected in individuals without cytopenias or hematological malignancies. While CH is considered part of normal ageing, CH is also significantly associated with cardiovascular disease, solid tumors, and hematological malignancies. In this review, we will discuss evidence linking CH with the development of AML, as well as describe challenges in and strategies for monitoring patients with high risk CH mutations.

引用

页码：177 / 185

页数：9

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