Age as a determinant of outcomes for patients with oral cancer

被引:39
作者
Goldenberg, David [1 ]
Brooksby, Craig [1 ]
Hollenbeak, Christopher S. [2 ]
机构
[1] Penn State Univ, Coll Med, Div Otolaryngol Head & Neck Surg, Hershey, PA 17033 USA
[2] Penn State Univ, Coll Med, Dept Surg & Publ Hlth Sci, Hershey, PA USA
关键词
Oral cancer; Tongue cancer; Squamous cell cancer; outcomes; Survival; Head and neck cancer; SQUAMOUS-CELL CARCINOMA; YOUNG-PATIENTS; TONGUE CANCER; ANTERIOR TONGUE; PATIENTS LESS; RISK-FACTORS; SURVIVAL; ADULTS; CAVITY; TRENDS;
D O I
10.1016/j.oraloncology.2009.01.011
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To determine whether survival outcomes of younger patients with oral cavity squamous cell cancer (OSCC) differs from older patients in the US. A retrospective cohort study using data from the Surveillance, Epidemiology and End Results (SEER) registry. We studied cases (n = 19681) of OSCC diagnosed from 1973 to 1999 and used age cutoffs at 40, 45, 50, and 55 years. Control groups of older patients were retrospectively matched on gender, race, cancer subsite, and stage of disease. Survival was estimated using the Kaplan-Meier method. A propensity score matching produced groups with similar distributions of patient and disease characteristics. Between these matched groups, younger patients had a significantly better five-year survival (age 40: 63.4% vs. 80.6%, p < 0.0001; age 45: 59.0% vs. 72.8%, p < 0.0001; age 50: 55.5% vs. 67.2%, p < 0.0001; age 55: 54.0% vs. 64.3%, p < 0.0001). These results confirm recent results using population-based data that suggest better overall survival in younger patients. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:E57 / E61
页数:5
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