Meroterpenoids and Steroids from the Marine-Derived Fungus Trametes sp. ZYX-Z-16

被引：12

作者：

Ren, Ziming ^{[1
]}

Yang, Li ^{[2
,3
]}

Ma, Qingyun ^{[2
,3
]}

Xie, Qingyi ^{[2
,3
]}

Dai, Haofu ^{[2
,3
]}

Sun, Kunlai ^{[1
]}

Zhao, Youxing ^{[2
,3
]}

机构：

[1] Zhejiang Ocean Univ, Zhejiang Prov Engn Technol Res Ctr Marine Biomed P, Sch Food & Pharm, Zhoushan 316022, Peoples R China

[2] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou 571101, Peoples R China

[3] Hainan Acad Trop Agr Resource, Hainan Key Lab Protect & Utilizat Trop Bioresource, Haikou 571101, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 24期

关键词：

marine-derived fungi; Trametes sp; spiromeroterpenoid; alpha-glucosidase inhibitory activity; antibacterial activity; ANTIAGING ERGOSTEROLS; GANODERMASIDES; CONSTITUENTS; INHIBITORS; SPORES; YO-2;

D O I：

10.3390/molecules27248782

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Marine fungi can metabolize structurally diverse active components, and have become an important source of drug lead molecules. In the present study, the chemical investigation on the EtOAc extract of the fermentation broth of the marine-derived fungus Trametes sp. ZYX-Z-16 led to the isolation of eight meroterpenoids (1-8), including two undescribed ones, together with ten ergostane steroid analogues (9-18). The structures of two new spiromeroterpenoids, asnovolin H (1) and asnovolin I (2), were determined based on 1D, 2D NMR, and HRESIMS spectroscopic data along with ECD spectra calculations. All compounds were tested for antibacterial and alpha-glucosidase inhibitory activity. Among them, compound 12 showed definite antibacterial activities against Staphylococcus aureus ATCC 6538 (MIC 32 mu g/mL) and Bacillus subtilis ATCC 6633 (MIC 16 mu g/mL). In addition, compounds 9 and 10 showed superior inhibitory activity, with IC50 values of 104.1 and 111.3 mu M, respectively, to the positive control acarbose (304.6 mu M).

引用

页数：11