Design of S-S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake

被引：21

作者：

Ishii, Satomu ^{[1
,2
]}

Sato, Shinichi ^{[1
]}

Asami, Hiroya ^{[3
]}

Hasegawa, Tomoko ^{[3
]}

Kohno, Jun-Ya ^{[3
]}

Nakamura, Hiroyuki ^{[1
]}

机构：

[1] Tokyo Inst Technol, Inst Innovat Res, Lab Chem & Life Sci, Midori Ku, R1-13,4259 Nagatsuta Cho, Yokohama, Kanagawa 2268503, Japan

[2] Tokyo Inst Technol, Sch Life Sci & Technol, Midori Ku, 4259 Nagatsuta Cho, Yokohama, Kanagawa 2268503, Japan

[3] Gakushuin Univ, Facil Sci, Dept Chem, Toshima Ku, 1-5-1 Mejiro, Tokyo 1718588, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 22期

关键词：

IR-LASER-ABLATION; NEUTRON-CAPTURE THERAPY; PHOTODISSOCIATION SPECTROSCOPY; BIOORTHOGONAL CHEMISTRY; BORON DELIVERY; DROPLET BEAM; TUMOR; AGENT;

D O I：

10.1039/c9ob00584f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An S-S bond containing maleimide-conjugated closo-dodecaborate (SSMID) was synthesised for identification of albumin binding sites. Three Lys residues, Lys221, Lys413 and Lys431, were identified as SSMID modification sites in addition to Cys34 in bovin serum albumin (BSA). Fluorescent-labelled MID-BSA was found to be accumulated in the cytosol of HeLa cells.

引用

页码：5496 / 5499

页数：4

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