Meningococcal protein antigens and vaccines

被引：52

作者：

Feavers, Ian M. ^{[1
]}

Pizza, Mariagrazia ^{[2
]}

机构：

[1] Natl Inst Biol Stand & Controls, Div Bacteriol, Potters Bar EN6 3QG, Herts, England

[2] Novartis Vaccines & Diagnost, I-53100 Siena, Italy

来源：

VACCINE | 2009年 / 27卷

关键词：

Meningococcus; Vaccines; Antigens; OUTER-MEMBRANE PROTEIN; MENINGITIDIS SEROGROUP-B; TRANSFERRIN-BINDING PROTEINS; FACTOR-H-BINDING; BACTERICIDAL IMMUNE-RESPONSE; HUMAN-ANTIBODY RESPONSE; HUMAN EPITHELIAL-CELLS; NEISSERIA-MENINGITIDIS; VESICLE VACCINE; MOLECULAR CHARACTERIZATION;

D O I：

10.1016/j.vaccine.2009.05.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of a comprehensive vaccine against meningococcal disease has been challenging. Recent developments in molecular genetics have provided both explanations for these challenges and possible solutions. Since genome sequence data became available there has been a marked increase in number of protein antigens that have been suggested as prospective vaccine components. This review catalogues the proposed vaccine candidates and examines the evidence for their inclusion in potential protein vaccine formulations. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：B42 / B50

页数：9

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