Risk factors of premature coronary artery disease in Iran: A systematic review and meta-analysis

被引：51

作者：

Poorzand, Hoorak ^{[1
]}

Tsarouhas, Konstantinos ^{[2
,3
,4
]}

Hozhabrossadati, Seyyed Amin ^{[5
]}

Khorrampazhouh, Nastaran ^{[5
]}

Bondarsahebi, Yones ^{[5
]}

Bacopoulou, Flora ^{[3
,4
]}

Rezaee, Ramin ^{[6
,7
,8
,9
]}

Esfehani, Reza Jafarzadeh ^{[10
]}

Morovatdar, Negar ^{[6
]}

机构：

[1] Mashhad Univ Med Sci, Atherosclerosis Prevent Res Ctr, Fac Med, Mashhad, Razavi Khorasan, Iran

[2] Univ Hosp Larissa, Dept Cardiol, Larisa, Greece

[3] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Ctr Adolescent Med, Dept Pediat 1,Med Sch,Chair Adolescent Hlth Care, Athens, Greece

[4] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, UNESCO, Dept Pediat 1,Med Sch,Chair Adolescent Hlth Care, Athens, Greece

[5] Mashhad Univ Med Sci, Fac Med, Students Res Comm, Mashhad, Razavi Khorasan, Iran

[6] Mashhad Univ Med Sci, Clin Res Unit, Fac Med, Mashhad, Razavi Khorasan, Iran

[7] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran

[8] Aristotle Univ Thessaloniki, Dept Chem Engn, Environm Engn Lab, Univ Campus, Thessaloniki, Greece

[9] Balkan Ctr, Ctr Interdisciplinary Res & Innovat, HERACLES Res Ctr Exposome & Hlth, Thessaloniki, Greece

[10] Mashhad Univ Med Sci, Fac Med, Dept Med Genet, Mashhad, Razavi Khorasan, Iran

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 49卷 / 07期

关键词：

diabetes mellitus; dyslipidaemia; hypertension; Iran; premature coronary artery disease; risk factors; smoking; MYOCARDIAL-INFARCTION SURVIVORS; HEART-DISEASE; LESS-THAN-OR-EQUAL-TO-40; YEARS; CARDIOVASCULAR-DISEASE; GLOBAL BURDEN; PART; YOUNG; ASSOCIATION; HOMOCYSTEINE; POLYMORPHISM;

D O I：

10.1111/eci.13124

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The aim of this study was to determine the mean age at which coronary artery disease (CAD) hase decreased in recent years in Iran. This systematic review and meta-analysis compares the prevalence of different risk factors of premature CAD (PCAD) in patients vs healthy individuals. Methods Medline, Web of Science, Embase and Scientific Information Database were searched for studies about PCAD risk factors in Iran until 28 October 2017. Observational studies of Iranians, comparing risk factors between patients with PCAD and age- and sex-matched healthy subjects, were included. Fixed-effects and random-effects model were used for pooling data. Odds ratio (OR) with 95% CI and mean difference were used for effect size estimation among studies. Results Twelve studies were eligible for meta-analysis. Diabetes mellitus (OR: 2.4, 95% CI: 1.9-3.03; P = 0.0001, I-2 = 25.5%; P = 0.2), family history of CAD (OR: 2.09, 95% CI: 1.22-3.6; P = 0.007, I-2 = 86%; P = 0.0001), dyslipidaemia (OR: 2.05, 95% CI: 1.15-3.64; P = 0.01, I-2 = 54%; P = 0.08), smoking (OR: 1.65, 95% CI: 1.11-2.46; P = 0.01, I-2 = 77.2%; P = 0.000) and hypertension (OR: 1.35, 95% CI: 1.21 to-1.50; P < 0.001, I-2 = 31%, P = 0.1) associated with PCAD. Sensitivity analysis demonstrated that patients with PCAD had significantly lower levels of high-density lipoprotein (HDL) cholesterol and significantly higher levels of triglycerides compared to healthy subjects (MD: -2.56, 95% CI: -3.54 to -1.58, P < 0.001, I-2 = 42%, P = 0.01 and MD: 21.17, 95% CI: 14.73-27.62, P < 0.001, I-2 = 80.12%, P < 0.001, respectively). It should be noted that although high levels of heterogeneity in LDL and HDL values among the studies were observed, when dyslipidaemia was studied as a binary variable, no significant heterogeneity among studies was observed. Conclusion Diabetes mellitus, family history of CAD, dyslipidaemia, smoking, and hypertension were significantly and positively associated with CAD in young adults compared to healthy age- and sex-matched population in Iran.

引用

页数：13

共 67 条

[1] Renin-angiotensin system genes polymorphism in Egyptians with premature coronary artery disease [J].