Epidermal Langerhans cells -: Changing views on their function in vivo

被引：60

作者：

Romani, Nikolaus ^{[1
]}

Ebner, Susanne

Tripp, Christoph H.

Flacher, Vincent

Koch, Franz

Stoitzner, Patrizia

机构：

[1] Innsbruck Med Univ, Dept Dermatol & Venerol, Innsbruck, Austria

[2] Kompetenzzentrum Med Tirol, Innsbruck, Austria

[3] Malaghan Inst Med Res, Wellington, New Zealand

来源：

IMMUNOLOGY LETTERS | 2006年 / 106卷 / 02期

基金：

奥地利科学基金会;

关键词：

Langerhans cells; dendritic cells; in vivo; function; skin; epidermis; contact hypersensitivity; ablation; CD207; langerin;

D O I：

10.1016/j.imlet.2006.05.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

New experimental models and methods have rendered the field of Langerhans cells very lively. An interesting and productive scientific debate as to the functions of Langerhans cells in vivo is currently going on. We have not yet reached the point, where the "pros" would weigh out the "cons", or vice versa. There is good evidence for a lack of Langerhans cell function and for down-regulatory Langerhans cell function in some models. On the other hand, there is also evidence for an active immunogenic and tolerogenic role of Langerhans cells. These recent developments will be discussed. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：119 / 125

页数：7

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