Preparation of chitosan/ethylcellulose complex microcapsule and its application in controlled release of vitamin D2

被引：138

作者：

Shi, XY ^{[1
]}

Tan, TW ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Coll Chem Engn, Beijing 100029, Peoples R China

来源：

BIOMATERIALS | 2002年 / 23卷 / 23期

基金：

中国国家自然科学基金;

关键词：

microcapsule; chitosan; vitamin D-2;

D O I：

10.1016/S0142-9612(02)00165-5

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A system which consists of chitosan (CS) microcores entrapped within enteric polymer is investigated. Vitamin D-2 (VD2) used as a model drug, was efficiently entrapped in CS microcores using spray drying and was microencapsulated by coating of ethylcellulose. The morphology and release properties of microcapsules were tested. The factors which influenced the preparation, including molecular weight of CS, concentration of CS solution, concentration of acetic acid and loading of VD2, were discussed. The results of release in vitro showed that the microcapsules could realize sustained release in intestine juice. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：4469 / 4473

页数：5

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