Effect of Acupuncture vs Sham Acupuncture or Waitlist Control on Joint Pain Related to Aromatase Inhibitors Among Women With Early-Stage Breast Cancer A Randomized Clinical Trial

被引:247
作者
Hershman, Dawn L. [1 ]
Unger, Joseph M. [2 ,3 ]
Greenlee, Heather [2 ]
Capodice, Jillian L. [4 ]
Lew, Danika L. [2 ,3 ]
Darke, Amy K. [2 ,3 ]
Kengla, Alice T. [5 ]
Melnik, Marianne K. [6 ]
Jorgensen, CarlaW. [7 ]
Kreisle, William H. [8 ]
Minasian, Lori M. [9 ]
Fisch, Michael J. [10 ]
Henry, N. Lynn [11 ]
Crew, Katherine D.
机构
[1] Columbia Univ, Med Ctr, New York, NY USA
[2] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA
[3] SWOG Stat & Data Management Ctr, Seattle, WA USA
[4] Mt Sinai Hosp, New York, NY 10029 USA
[5] Kaiser Permanente Med Ctr, Walnut Creek, CA USA
[6] Spectrum Hlth Med Grp, Grand Rapids, MI USA
[7] NCORP Carolinas Greenville Hlth Syst, Greenville, SC USA
[8] St Lukes Mt States Tumor Inst PCRC NCORP, Boise, ID USA
[9] NCI, Canc Prevent Div, Bethesda, MD 20892 USA
[10] AIM Specialty Hlth, Chicago, IL USA
[11] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2018年 / 320卷 / 02期
基金
美国国家卫生研究院;
关键词
QUALITY-OF-LIFE; MUSCULOSKELETAL SYMPTOMS; IMMPACT RECOMMENDATIONS; HORMONAL-THERAPY; ARTHRALGIA; OUTCOMES; PLACEBO; DISCONTINUATION; MULTICENTER; VALIDATION;
D O I
10.1001/jama.2018.8907
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
IMPORTANCE Musculoskeletal symptoms are the most common adverse effects of aromatase inhibitors and often result in therapy discontinuation. Small studies suggest that acupuncture may decrease aromatase inhibitor-related joint symptoms. OBJECTIVE To determine the effect of acupuncture in reducing aromatase inhibitor-related joint pain. DESIGN, SETTING, AND PATIENTS Randomized clinical trial conducted at 11 academic centers and clinical sites in the United States from March 2012 to February 2017 (final date of follow-up, September 5, 2017). Eligible patients were postmenopausal women with early-stage breast cancer who were taking an aromatase inhibitor and scored at least 3 on the Brief Pain Inventory Worst Pain (BPI-WP) item (score range, 0-10; higher scores indicate greater pain). INTERVENTIONS Patients were randomized 2: 1: 1 to the true acupuncture (n = 110), sham acupuncture (n = 59), or waitlist control (n = 57) group. True acupuncture and sham acupuncture protocols consisted of 12 acupuncture sessions over 6 weeks (2 sessions per week), followed by 1 session per week for 6 weeks. The waitlist control group did not receive any intervention. All participants were offered 10 acupuncture sessions to be used between weeks 24 and 52. MAIN OUTCOMES AND MEASURES The primary end point was the 6-week BPI-WP score. Mean 6-week BPI-WP scores were compared by study group using linear regression, adjusted for baseline pain and stratification factors (clinically meaningful difference specified as 2 points). RESULTS Among 226 randomized patients (mean [SD] age, 60.7 [8.6] years; 88% white; mean [SD] baseline BPI-WP score, 6.6 [1.5]), 206 (91.1%) completed the trial. From baseline to 6 weeks, the mean observed BPI-WP score decreased by 2.05 points (reduced pain) in the true acupuncture group, by 1.07 points in the sham acupuncture group, and by 0.99 points in the waitlist control group. The adjusted difference for true acupuncture vs sham acupuncture was 0.92 points (95% CI, 0.20-1.65; P = .01) and for true acupuncture vs waitlist control was 0.96 points (95% CI, 0.24-1.67; P = .01). Patients in the true acupuncture group experienced more grade 1 bruising compared with patients in the sham acupuncture group (47% vs 25%; P = .01). CONCLUSIONS AND RELEVANCE Among postmenopausal women with early-stage breast cancer and aromatase inhibitor-related arthralgias, true acupuncture compared with sham acupuncture or with waitlist control resulted in a statistically significant reduction in joint pain at 6 weeks, although the observed improvement was of uncertain clinical importance.
引用
收藏
页码:167 / 176
页数:10
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