Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death

被引：539

作者：

Chinnaiyan, AM ^{[1
]}

ORourke, K ^{[1
]}

Lane, BR ^{[1
]}

Dixit, VM ^{[1
]}

机构：

[1] UNIV MICHIGAN,SCH MED,DEPT PATHOL,ANN ARBOR,MI 48109

来源：

SCIENCE | 1997年 / 275卷 / 5303期

关键词：

D O I：

10.1126/science.275.5303.1122

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previous genetic studies of the nematode Caenorhabditis elegans identified three important components of the cell death machinery. CED-3 and CED-4 function to kill cells, whereas CED-9 protects cells from death. Here CED-9 and its mammalian homolog Bcl-x(L) (a member of the Bcl-2 family of cell death regulators) were both found to interact with and inhibit the function of CED-4. In addition, analysis revealed that CED-4 can simultaneously interact with CED-3 and its mammalian counterparts interleukin-1 beta-converting enzyme (ICE) and FLICE. Thus, CED-4 plays a central role in the cell death pathway, biochemically linking CED-9 and the Bcl-2 family to CED3 and the ICE family of pro-apoptotic cysteine proteases.

引用

页码：1122 / 1126

页数：5

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