A New Cytotoxic Gymnomitrane Sesquiterpene from Ganoderma lucidum Fruiting Bodies

被引：0
作者：
Pham Thanh Binh [1 ]
Descoutures, Dimitri [2 ,3 ]
Nguyen Hai Dang [1 ]
Nguyen Phuong Dai Nguyen [4 ]
Nguyen Tien Dat [1 ]
机构：
[1] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam
[2] Univ Sci & Technol Hanoi, Hanoi, Vietnam
[3] Univ Lyon 1, F-69622 Villeurbanne, France
[4] Univ Tay Nguyen, Dept Biol, Dac Lac City 630000, Vietnam
来源：
NATURAL PRODUCT COMMUNICATIONS | 2015年 / 10卷 / 11期
关键词：
Ganoderma lucidum; Gymnomitrane; Sesquiterpene; EGFR-TKI;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new gymnomitrane-type sesquiterpenoid, gymnomitrane-3 alpha,5 alpha,9 beta,15-tetrol (1), was isolated from the fruiting body of Ganoderma lucidum. Its structure was elucidated using spectroscopic methods. This compound significantly inhibited the growth of epidermal growth factor receptor-tyrosine kinase inhibitor EGFR-TKI-resistant human lung cancer A549 and human prostate cancer PC3 cell lines.
引用
收藏
页码：1911 / 1912
页数：2
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