Tm3+-Sensitized NIR-II Fluorescent Nanocrystals for In Vivo Information Storage and Decoding

被引：243

作者：

Zhang, Hongxin ^{[1
,2
]}

Fan, Yong ^{[1
,2
]}

Pei, Peng ^{[1
,2
]}

Sun, Caixia ^{[1
,2
]}

Lu, Lingfei ^{[1
,2
]}

Zhang, Fan ^{[1
,2
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai Key Lab Mol Catalysis & Innovat Mat, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

[2] Fudan Univ, iChem, Shanghai 200433, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 30期

基金：

中国国家自然科学基金;

关键词：

in vivo imaging; lanthanide-doped nanocrystals; multiplexed encoding; NIR-II excitation; UP-CONVERSION; NANOPARTICLES; WINDOW;

D O I：

10.1002/anie.201903536

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In vivo fluorescence imaging in the second near-infrared window (NIR-II) affords deep-tissue penetration and high spatial resolution. Herein, we present a new type of Tm3+-sensitized lanthanide nanocrystals with both excitation (1208 nm) and emission (1525 nm) located in the NIR-II window for in vivo optical information storage and decoding. Taking advantage of the tunable fluorescence lifetimes, the optical multiplexed encoding capacity is enhanced accordingly. Micro-devices with QR codes featuring the NIR-II fluorescence-lifetime multiplexed encoding were implanted into mice and were successfully decoded through time-gated fluorescence imaging technology.

引用

页码：10153 / 10157

页数：5

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