Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas

被引:113
作者
Dorta, RG
Landman, G
Kowalski, LP
Lauris, JRP
Latorre, MRDO
Oliveira, DT
机构
[1] Univ Sao Paulo, Bauru Dent Sch, Area Pathol, Dept Oral Med, Bauru, Brazil
[2] Canc Hosp, Dept Pathol, Sao Paulo, Brazil
[3] Canc Hosp, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, Brazil
[4] Bauru Dent Sch, Dept Paediat Dent Orthodont & Publ Hlth, Sao Paulo, Brazil
[5] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Sao Paulo, Brazil
关键词
eosinophilia; eosinophil; squamous cell carcinoma; oral cancer; prognosis;
D O I
10.1046/j.1365-2559.2002.01437.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Aims: Tumour-associated tissue eosinophilia has been described in many sites, including head and neck. The mechanism of eosinophil recruitment and its role in tumours has not yet been defined, and its presence has been related to a favourable as well as unfavourable prognosis. The aim of this study was to evaluate the influence of tumour-associated tissue eosinophilia on the prognosis of 125 oral squamous cell carcinoma patients. Methods and results: The number of eosinophils was obtained by morphometric analysis and ranged from 0 to 392 per mm(2). Tumour-associated tissue eosinophilia was classified according to intensity as mild, moderate, or intense and correlated statistically to the intensity of the mononuclear inflammatory infiltrate as well as to the location of the eosinophilic inflammatory infiltrate. The multivariate analysis demonstrated that intense tumour-associated tissue eosinophilia is an independent favourable prognostic factor for oral squamous cell carcinomas. Conclusions: These findings suggest an anti-tumoral role of eosinophils not as yet well understood that should be better investigated.
引用
收藏
页码:152 / 157
页数:6
相关论文
共 36 条
[1]   Intercellular cell adhesion molecule-1,vascular cell adhesion molecule-1, and regulated on activation normal T cell expressed and secreted are expressed by human breast carcinoma cells and support eosinophil adhesion and activation [J].
Ali, S ;
Kaur, J ;
Patel, KD .
AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (01) :313-321
[2]   Tumour-associated tissue eosinophilia in head and neck squamous-cell carcinoma [J].
Deron, P ;
Goossens, A ;
Halama, AR .
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES, 1996, 58 (03) :167-170
[3]  
Dessy E, 1986, Acta Otorhinolaryngol Ital, V6, P357
[4]  
Fernández-Aceñero MJ, 2000, CANCER-AM CANCER SOC, V88, P1544, DOI 10.1002/(SICI)1097-0142(20000401)88:7<1544::AID-CNCR7>3.0.CO
[5]  
2-S
[6]  
GHIABI M, 1992, CANCER RES, V52, P389
[7]   THE BIOLOGY OF THE EOSINOPHILIC LEUKOCYTE [J].
GLEICH, GJ ;
ADOLPHSON, CR ;
LEIFERMAN, KM .
ANNUAL REVIEW OF MEDICINE, 1993, 44 :85-101
[8]   THE PROGNOSTIC-SIGNIFICANCE OF STROMAL EOSINOPHILIA IN HEAD AND NECK-CANCER .2. [J].
GOLDSMITH, MM ;
CRESSON, DH ;
ASKIN, FB .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1987, 96 (04) :319-324
[9]   THE IMPORTANCE OF THE EOSINOPHIL IN HEAD AND NECK-CANCER [J].
GOLDSMITH, MM ;
BELCHIS, DA ;
CRESSON, DH ;
MERRITT, WD ;
ASKIN, FB .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1992, 106 (01) :27-33
[10]   PROGNOSTIC FACTORS FOR WELL-DIFFERENTIATED SQUAMOUS-CELL CARCINOMA IN THE ORAL CAVITY WITH EMPHASIS ON IMMUNOHISTOCHEMICAL EVALUATION [J].
HORIUCHI, K ;
MISHIMA, K ;
OHSAWA, M ;
SUGIMURA, M ;
AOZASA, K .
JOURNAL OF SURGICAL ONCOLOGY, 1993, 53 (02) :92-96