Wnt/β-catenin signalling and the dynamics of fate mouse embryos and embryonic stem (ES) cells

被引：27
作者：
Munoz-Descalzo, Silvia [1 ]
Hadjantonakis, Anna-Katerina [2 ]
Arias, Alfonso Martinez [3 ]
机构：
[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England
[2] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Dev Biol Program, New York, NY 10065 USA
[3] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2015年 / 47-48卷
关键词：
Wnt signalling; Embryogenesis; Signalling; Stem cells; Mouse; ANTERIOR-POSTERIOR AXIS; BETA-CATENIN; SELF-RENEWAL; GERM LAYER; NEURAL DIFFERENTIATION; CLONAL ANALYSIS; GROUND-STATE; WNT; EPIBLAST; PLURIPOTENCY;
D O I：
10.1016/j.semcdb.2015.08.011
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Wnt/beta-catenin signalling is a widespread cell signalling pathway with multiple roles during vertebrate development. In mouse embryonic stem (mES) cells, there is a dual role for beta-catenin: it promotes differentiation when activated as part of the Wnt/beta-catenin signalling pathway, and promotes stable pluripotency independently of signalling. Although mES cells resemble the preimplantation epiblast progenitors, the first requirement for Wnt/beta-catenin signalling during mouse development has been reported at implantation [1,2]. The relationship between beta-catenin and pluripotency and that of mES cells with epiblast progenitors suggests that beta-catenin might have a functional role during preimplantation development. Here we summarize the expression and function of Wnt/beta-catenin signalling elements during the early stages of mouse development and consider the reasons why the requirement in ES cells do not reflect the embryo. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：101 / 109
页数：9
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