Localisation of glutamate receptors in the substantia nigra pars compacta of the monkey

被引：0
作者：
Ong, WY
He, Y
Garey, LJ
机构：
[1] NATL UNIV SINGAPORE,DEPT ANAT,SINGAPORE 119260,SINGAPORE
[2] MT SINAI SCH MED,FISHBERG RES CTR NEUROBIOL,DEPT NEUROBIOL,NEW YORK,NY 10029
[3] CHARING CROSS HOSP,IMPERIAL COLL,SCH MED,DIV NEUROSCI,LONDON W6 8RF,ENGLAND
来源：
JOURNAL OF BRAIN RESEARCH-JOURNAL FUR HIRNFORSCHUNG | 1997年 / 38卷 / 03期
关键词：
glutamate receptors; ionotropic subunits; metabotropic receptors; substantia nigra pars compacta; macaque monkey;
D O I：
暂无
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
The distribution of ionotropic glutamate receptor subunits GluR1, GluR2/3 and NMDAR1, and metabotropic receptor mGluR1 alpha was studied in the monkey substantia nigra. High levels of immunoreactivity to GluR1, GluR2/3 and NMDAR1, and moderate levels of immunoreactivity to mGluR1 alpha were observed in the substantia nigra pars compacta. GluR1 and GluR2/3 were mostly in cell bodies and larger stem dendrites, whilst NMDAR1 and mGluR1 alpha were present on medium sized and small dendrites, respectively. The substantia nigra receives glutamatergic afferents from the subthalamic nucleus and the frontal cortex. Overactivity of the subthalamic nucleus, coupled with high levels of glutamate receptors on the neurons in the pars compacta, could predispose these neurons to excitotoxic injury, and could contribute to the development of Parkinson's disease.
引用
收藏
页码：291 / 298
页数：8
相关论文
共 50 条
[31]   Protective effect of curcumin against rotenone-induced substantia nigra pars compacta neuronal dysfunction [J].
Darbinyan, L., V ;
Simonyan, K., V ;
Hambardzumyan, L. E. ;
Manukyan, L. P. ;
Badalyan, S. H. ;
Sarkisian, V. H. .
METABOLIC BRAIN DISEASE, 2022, 37 (04) :1111-1118
[32]   Alterations in the proportions of skeletal muscle proteins following a unilateral lesion to the substantia nigra pars compacta of rats [J].
Sliwinski, A ;
Stanic, D ;
Finkelstein, DI ;
Ilic, M ;
West, JM ;
Dooley, PC .
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2005, 26 (2-3) :149-155
[33]   Evidence for the substantia nigra pars compacta as an essential component of a memory system independent of the hippocampal memory system [J].
Da Cunha, C ;
Wietzikoski, S ;
Wietzikoski, EC ;
Miyoshi, E ;
Ferro, MM ;
Anselmo-Franci, JA ;
Canteras, NS .
NEUROBIOLOGY OF LEARNING AND MEMORY, 2003, 79 (03) :236-242
[34]   Resveratrol prevents akinesia and restores neuronal tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta of diabetic rats [J].
Bagatini, Pamela Brambilla ;
Xavier, Leder Leal ;
Neues, Laura Tartan ;
Saur, Lisiani ;
Barbosa, Silvia ;
Baptista, Pedro Porto Alegre ;
Augustin, Otavio Americo ;
de Senna, Priscylla Nunes ;
Mestriner, Regis Gemerasca ;
Souto, Andre Arigony ;
Achaval, Matilde .
BRAIN RESEARCH, 2014, 1592 :101-112
[35]   Combined enrichment of neuromelanin granules and synaptosomes from human substantia nigra pars compacta tissue for proteomic analysis [J].
Plum, S. ;
Helling, S. ;
Theiss, C. ;
Leite, R. E. P. ;
May, C. ;
Jacob-Filho, W. ;
Eisenacher, M. ;
Kuhlmann, K. ;
Meyer, H. E. ;
Riederer, P. ;
Grinberg, L. T. ;
Gerlach, M. ;
Marcus, K. .
JOURNAL OF PROTEOMICS, 2013, 94 :202-206
[36]   The Lesion of the Rat Substantia Nigra pars compacta Dopaminergic Neurons as a Model for Parkinson's Disease Memory Disabilities [J].
Claudio Da Cunha ;
Miriam Elizabeth Mendes Angelucci ;
Newton S. Canteras ;
Susan Wonnacott ;
Reinaldo N. Takahashi .
Cellular and Molecular Neurobiology, 2002, 22 :227-237
[37]   Excitatory drive from the Subthalamic nucleus attenuates GABAergic transmission in the Substantia Nigra pars compacta via endocannabinoids [J].
Freestone, Peter S. ;
Wu, Xi Hau ;
de Guzman, Gabriel ;
Lipski, Janusz .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2015, 767 :144-151
[38]   Effects of bacterial melanin on motor recovery and regeneration after unilateral destruction of Substantia Nigra pars compacta in rats [J].
Petrosyan, T. R. ;
Gevorkyan, O. V. ;
Chavushyan, V. A. ;
Meliksetyan, I. B. ;
Hovsepyan, A. S. ;
Manvelyan, L. R. .
NEUROPEPTIDES, 2014, 48 (01) :37-46
[39]   GLUTAMATERGIC AND CHOLINERGIC INPUTS FROM THE PEDUNCULOPONTINE TEGMENTAL NUCLEUS TO DOPAMINE NEURONS IN THE SUBSTANTIA-NIGRA PARS COMPACTA [J].
FUTAMI, T ;
TAKAKUSAKI, K ;
KITAI, ST .
NEUROSCIENCE RESEARCH, 1995, 21 (04) :331-342
[40]   The lesion of the rat substantia nigra pars compacta dopaminergic neurons as a model for Parkinson's disease memory disabilities [J].
Da Cunha, C ;
Angelucci, MEM ;
Canteras, NS ;
Wonnacott, S ;
Takahashi, RN .
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2002, 22 (03) :227-237
12345