In vitro Effects of Glycyrrhetinic Acid on the Growth of Clinical Isolates of Candida albicans

被引：26

作者：

Pellati, Donatella ^{[1
,2
]}

Fiore, Cristina ^{[2
]}

Armanini, Decio ^{[2
]}

Rassu, Mario ^{[3
]}

Bertoloni, Giulio ^{[1
]}

机构：

[1] Univ Padua, Dept Histol Microbiol & Med Biotechnol, I-35121 Padua, Italy

[2] Univ Padua, Dept Med & Surg Sci, I-35121 Padua, Italy

[3] San Bortolo Hosp, Dept Microbiol, I-36100 Vicenza, Italy

来源：

PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 04期

关键词：

Glycyrrhiza glabra L; 18-beta glycyrrhetinic acid (18-beta GA); Candida albicans; recurrent vulvovaginal candidiasis (RVVC); LICORICE; MECHANISM;

D O I：

10.1002/ptr.2693

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Compounds derived from Glycyrrhiza glabra L. root have been used widely for centuries for their numerous therapeutic properties. The present study aimed to test the in vitro activity against Candida albicans strains of the compound 18-beta glycyrrhetinic acid (18-beta GA), derived from the root of Glycyrrhiza species. This antimicrobial activity was assessed using the National Committee for Clinical Laboratory Standards (NCCLS) method on C. albicans strains that were isolated from patients with recurrent vulvovaginal candidiasis (RVVC). The in vitro growth of the C. albicans strains was markedly reduced, in a pH-dependent manner, by relatively low doses (6.2 mu g/mL) of 18-beta GA. The results demonstrate that 18-beta GA is a promising biological alternative for the topical treatment of recurrent vulvovaginal candidiasis (RVVC). Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：572 / 574

页数：3

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