Subversion of nutritional immunity by the pathogenic Neisseriae

被引:32
作者
Cornelissen, Cynthia Nau [1 ]
机构
[1] Virginia Commonwealth Univ, Sch Med, Dept Microbiol & Immunol, Box 980678, Richmond, VA 23298 USA
来源
PATHOGENS AND DISEASE | 2018年 / 76卷 / 01期
基金
美国国家卫生研究院;
关键词
nutritional immunity; Neisseria gonorrhoeae; Neisseria meningitidis; transition metals; iron and zinc piracy; TRANSFERRIN-BINDING PROTEIN-1; OUTER-MEMBRANE PROTEIN; GONOCOCCAL TRANSFERRIN; ESCHERICHIA-COLI; PHASE VARIATION; EPITHELIAL-CELLS; IRON PIRACY; STRUCTURAL-CHARACTERIZATION; MENINGOCOCCAL DISEASE; LACTOFERRIN RECEPTOR;
D O I
10.1093/femspd/ftx112
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The pathogenic Neisseria species, including Neisseria meningitidis and Neisseria gonorrhoeae, are obligate human pathogens that cause significant morbidity and mortality. The success of these pathogens, with regard to causing disease in humans, is inextricably linked to their ability to acquire necessary nutrients in the hostile environment of the host. Humans deploy a significant arsenal of weaponry to defend against bacterial pathogens, not least of which are the metal-sequestering proteins that entrap and withhold transition metals, including iron, zinc and manganese, from invaders. This review will discuss the general strategies that bacteria employ to overcome these metal-sequestering attempts by the host, and then will focus on the relatively uncommon 'metal piracy' approaches utilized by the pathogenic Neisseria for this purpose. Because acquiring metals from the environment is critical to microbial survival, interfering with this process could impede growth and therefore disease initiation or progression. This review will also discuss how interfering with metal uptake by the pathogenic Neisseriae could be deployed in the development of novel or improved preventative or therapeutic measures against these important pathogens.
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页数:14
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