The 'effectiveness' scale - therapeutic outcome of pharmacologic therapies for ED: an international consensus panel report

被引：36

作者：

Carson, C

Giuliano, F

Goldstein, I

Hatzichristou, D

Hellstrom, W

Lue, T

Montorsi, F

Munarriz, R

Nehra, A

Porst, H

Rosen, R

机构：

[1] Boston Univ, Sch Med, Inst Sexual Med, Dept Urol, Boston, MA 02118 USA

[2] Univ N Carolina, Dept Urol, Chapel Hill, NC USA

[3] Acad Hosp Bicetre, Le Kremlin Bicetre, France

[4] Aristotle Univ Thessaloniki, Dept Urol 2, Thessaloniki, Greece

[5] Aristotle Univ Thessaloniki, Ctr Sexual & Reprod Hlth, Thessaloniki, Greece

[6] Tulane Univ, Sch Med, Dept Urol, New Orleans, LA 70112 USA

[7] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA

[8] Univ Vita Salute San Raffaele, Dept Urol, Milan, Italy

[9] Mayo Clin, Dept Urol, Rochester, MN USA

[10] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Psychiat, Piscataway, NJ 08854 USA

[11] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Med, Piscataway, NJ 08854 USA

来源：

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH | 2004年 / 16卷 / 03期

关键词：

therapeutic effectiveness; PDE-5; therapy; erectile dysfunction; treatment satisfaction; drug efficacy; tolerability;

D O I：

10.1038/sj.ijir.3901227

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Despite availability of outcome measures and scales for assessing erectile dysfunction (ED) treatment efficacy, guidelines are not available for assessing broader therapeutic outcomes or defining treatment failure in ED. An International Consensus Advisory Panel was convened to develop guidelines, definitions and a new algorithm for evaluating treatment effectiveness in ED. These new guidelines are recommended for use in both research and clinical practice. A multidisciplinary, international panel, consisting of 11 senior researchers and clinicians, was convened to address pertinent issues concerning therapeutic outcome assessment for ED. The panel utilized a modified Delphi method of consensus development and proposed a new model for outcomes assessment. This model is inherently testable, using existing instruments and current methods of assessment. Following a comprehensive literature review and discussion, the Panel recommended adoption of a new treatment effectiveness conceptual framework or theoretical model for assessing therapeutic outcomes in ED. Treatment effectiveness is presumed to be a combined function of two other factors, treatment response and treatment satisfaction. Treatment response is based on the combined assessment of efficacy and tolerability, and treatment satisfaction on the combined assessment of patient and partner satisfaction. Taken together, these two domains define an overall domain of treatment effectiveness. This therapeutic index would be derived by independently assessing treatment efficacy and satisfaction by means of event logs, questionnaires or the more typical patient interview methods. In conclusion, the Ad Hoc Advisory Consensus Panel recommends adoption of a new framework or conceptual model for conducting ED outcome trials or clinical research. The concept of 'treatment effectiveness' is proposed as a new 'umbrella concept' or distal outcome to be evaluated.

引用

页码：207 / 213

页数：7

共 7 条

[1] Studying the effectiveness of psychotherapy - How well can clinical trials do the job? [J].