Limited Hepatitis B Virus Replication Space in the Chronically Hepatitis C Virus-Infected Liver

被引：28

作者：

Wieland, S. F. ^{[1
]}

Asabe, S. ^{[1
]}

Engle, R. E. ^{[2
]}

Purcell, R. H. ^{[2
]}

Chisari, F. V. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[2] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 09期

关键词：

TRANSGENIC MICE; GENOMIC ANALYSIS; VIRAL CLEARANCE; HOST RESPONSE; HUH-7; CELLS; CHIMPANZEES; INTERFERON; EXPRESSION; COINFECTION; DISEASE;

D O I：

10.1128/JVI.03553-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We compared the kinetics and magnitude of hepatitis B virus (HBV) infection in hepatitis C virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes was drastically reduced. These results suggest that establishment of HBV infection and its replication space is limited by the antiviral effects of type I interferon in the chronically HCV-infected liver.

引用

页码：5184 / 5188

页数：5

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