Secretion of interleukin-17 by CD8+T cells expressing CD146 (MCAM)

被引：33

作者：

Dagur, Pradeep K. ^{[1
]}

Biancotto, Angelique ^{[2
]}

Stansky, Elena ^{[1
]}

Sen, H. Nida ^{[3
]}

Nussenblatt, Robert B. ^{[2
,3
]}

McCoy, J. Philip ^{[1
,2
]}

机构：

[1] NHLBI, Hematol Branch, Bethesda, MD 20892 USA

[2] NIH, Ctr Human Immunol Autoimmun & Inflammat, Bethesda, MD 20892 USA

[3] NEI, Clin Immunol Sect, NIH, Bethesda, MD 20892 USA

来源：

CLINICAL IMMUNOLOGY | 2014年 / 152卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

CD146/MCAM; Tc17; Inflammation; Class I antigen; T-CELLS; BIRDSHOT CHORIORETINOPATHY; AUTOIMMUNE-DISEASES; BEHCETS-DISEASE; SUSCEPTIBILITY; LYMPHOCYTES; MARKER; IL-17; DIFFERENTIATION; IDENTIFICATION;

D O I：

10.1016/j.clim.2014.01.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-17 (IL-17) has been associated with the pathogenesis of numerous autoimmune diseases. CD4+ T cells secreting IL-17 are termed Th17 cells. CD8+ T cells, designated Tc17 cells, are also capable of secreting IL-17. Here we describe a population of Tc17 cells characterized by the expression of surface CD146, an endothelial adhesion molecule. These cells display signatures of a human Tc17 genotype and phenotype. Circulating CD8+CD146+ T cells are present in tow levels in healthy adults. Elevations in CD8+CD146+ T cells are found in Behcet's disease and birdshot retinochoroidopathy, which have been reported to have HLA class I associations. Sarcoidosis does not have a class I association and displays an increase in CD4+ CD146+ T cells but not in CD8+CD146+ T cells. CD146 on these cells may facilitate their ability to bind to, and migrate through, endothelium, as has been reported for CD4+CD146+ T cells. Published by Elsevier Inc.

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收藏

页码：36 / 47

页数：12

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