β-Blocker in Septic Shock Management

被引：2

作者：

Durand, M. ^{[1
]}

Louis, H. ^{[2
]}

Fritz, C. ^{[1
]}

Levy, B. ^{[1
]}

Kimmoun, A. ^{[1
]}

机构：

[1] INSERM U1116, Defaillance Circulatoire Aigue & Chron, Fac Med Nancy, Equipe 2, F-54500 Vandoeuvre Les Nancy, France

[2] CHRU Nancy, Serv Reanimat & Med Intens Brabois, F-54511 Vandoeuvre Les Nancy, France

来源：

MEDECINE INTENSIVE REANIMATION | 2019年 / 28卷 / 02期

关键词：

Sepsis; Septic shock; beta-blocker; Hemodynamic; Adrenergic receptor; NECROSIS-FACTOR-ALPHA; HEART-RATE CONTROL; SYSTEMIC INFLAMMATION; VASCULAR FUNCTION; SEVERE SEPSIS; ADRENERGIC-BLOCKADE; IMPROVES SURVIVAL; RAT MODEL; ESMOLOL; DEXMEDETOMIDINE;

D O I：

10.3166/rea-2019-0095

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adrenoreceptors alpha and particularly beta are the main targets of epinephrine and norepinephrine released by the sympathetic system. During septic shock, dysautonomia could be defined as a prolonged over-activation of the sympathetic system. Dysautonomia is among other abnormalities, responsible for cardiac and vascular hypo-contractility and immunosuppression. Thus, during septic shock, early administration of beta-blockers might limit the deleterious effects of sympathetic over-stimulation. However, if experimental data are convincing, formal clinical evidences are still lacking.

引用

页码：126 / 143

页数：18

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