The FGF family: biology, pathophysiology and therapy

被引：1508

作者：

Beenken, Andrew ^{[1
]}

Mohammadi, Moosa ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Pharmacol, New York, NY 10016 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2009年 / 8卷 / 03期

关键词：

FIBROBLAST-GROWTH-FACTOR; BILE-ACID SYNTHESIS; DOMINANT HYPOPHOSPHATEMIC RICKETS; ENDOTHELIAL-CELL PROLIFERATION; ACTIVATED-RECEPTOR-GAMMA; CHRONIC KIDNEY-DISEASE; SPINAL-CORD REPAIR; PHASE-II TRIAL; AUTOSOMAL-DOMINANT; MULTIPLE-MYELOMA;

D O I：

10.1038/nrd2792

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development. Several mitogenic, cytoprotective and angiogenic therapeutic applications of FGFs are already being explored, and the recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in bile acid, glucose and phosphate homeostasis has sparked renewed interest in the pharmacological potential of this family. This Review discusses traditional applications of recombinant FGFs and small-molecule FGF receptor kinase inhibitors in the treatment of cancer and cardiovascular disease and their emerging potential in the treatment of metabolic syndrome and hypophosphataemic diseases.

引用

页码：235 / 253

页数：19

共 278 条

[101] Inhibition of growth hormone signaling by the fasting-induced hormone FGF21 [J].

Inagaki, Takeshi ;

Lin, Vicky Y. ;

Goetz, Regina ;

Mohammadi, Moosa ;

Mangelsdorf, David J. ;

Kliewer, Steven A. .

CELL METABOLISM, 2008, 8 (01) :77-83

[102] Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21 [J].

Inagaki, Takeshi ;

Dutchak, Paul ;

Zhao, Guixiang ;

Ding, Xunshan ;

Gautron, Laurent ;

Parameswara, Vinay ;

Li, Yong ;

Goetz, Regina ;

Mohammadi, Moosa ;

Esser, Victoria ;

Elmquist, Joel K. ;

Gerard, Robert D. ;

Burgess, Shawn C. ;

Hammer, Robert E. ;

Mangelsdorf, David J. ;

Kliewer, Steven A. .

CELL METABOLISM, 2007, 5 (06) :415-425

[103] Role of the vitamin D receptor in FGF23 action on phosphate metabolism [J].

Inoue, Y ;

Segawa, H ;

Kaneko, I ;

Yamanaka, S ;

Kusano, K ;

Kawakami, E ;

Furutani, J ;

Ito, M ;

Kuwahata, M ;

Saito, H ;

Fukushima, N ;

Kato, S ;

Kanayama, H ;

Miyamoto, K .

BIOCHEMICAL JOURNAL, 2005, 390 (01) :325-331

[104] Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho [J].

Ito, S ;

Fujimori, T ;

Furuya, A ;

Satoh, J ;

Nabeshima, Y ;

Nabeshima, Y .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (08) :2202-2208

[105] Evolution of the Fgf and Fgfr gene families [J].

Itoh, N ;

Ornitz, DM .

TRENDS IN GENETICS, 2004, 20 (11) :563-569

[106] Myocardial ischemia enhances the expression of acidic fibroblast growth factor in human pericardial fluid [J].

Iwakura, A ;

Fujita, M ;

Ikemoto, M ;

Hasegawa, K ;

Nohara, R ;

Sasayama, S ;

Miyamoto, S ;

Yamazato, A ;

Tambara, K ;

Komeda, M .

HEART AND VESSELS, 2000, 15 (03) :112-116

[107] FGF21 is an Akt-regulated myokine [J].

Izumiya, Yasuhiro ;

Bina, Holly A. ;

Ouchi, Noriyuki ;

Akasaki, Yuichi ;

Kharitonenkov, Alexei ;

Walsh, Kenneth .

FEBS LETTERS, 2008, 582 (27) :3805-3810

[108] THE HUMAN FIBROBLAST GROWTH-FACTOR RECEPTOR GENES - A COMMON STRUCTURAL ARRANGEMENT UNDERLIES THE MECHANISMS FOR GENERATING RECEPTOR FORMS THAT DIFFER IN THEIR 3RD IMMUNOGLOBULIN DOMAIN [J].

JOHNSON, DE ;

LU, J ;

CHEN, H ;

WERNER, S ;

WILLIAMS, LT .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (09) :4627-4634

[109] Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. [J].

Jonsson, KB ;

Zahradnik, R ;

Larsson, T ;

White, KE ;

Sugimoto, T ;

Imanishi, Y ;

Yamamoto, T ;

Hampson, G ;

Koshiyama, H ;

Ljunggren, Ö ;

Oba, K ;

Yang, IM ;

Miyauchi, A ;

Econs, MJ ;

Lavigne, J ;

Jüppner, H .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (17) :1656-1663

[110] Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis [J].

Kan, S ;

Elankko, N ;

Johnson, D ;

Cornejo-Roldan, L ;

Cook, J ;

Reich, EW ;

Tomkins, S ;

Verloes, A ;

Twigg, SRF ;

Rannan-Eliya, S ;

McDonald-McGinn, DM ;

Zackai, EH ;

Wall, SA ;

Muenke, M ;

Wilkie, AOM .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (02) :472-486

← 6 7 8 9 10 11 12 13 14 15 →