The FGF family: biology, pathophysiology and therapy

被引：1470
作者：
Beenken, Andrew [1 ]
Mohammadi, Moosa [1 ]
机构：
[1] NYU, Sch Med, Dept Pharmacol, New York, NY 10016 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2009年 / 8卷 / 03期
关键词：
FIBROBLAST-GROWTH-FACTOR; BILE-ACID SYNTHESIS; DOMINANT HYPOPHOSPHATEMIC RICKETS; ENDOTHELIAL-CELL PROLIFERATION; ACTIVATED-RECEPTOR-GAMMA; CHRONIC KIDNEY-DISEASE; SPINAL-CORD REPAIR; PHASE-II TRIAL; AUTOSOMAL-DOMINANT; MULTIPLE-MYELOMA;
D O I：
10.1038/nrd2792
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development. Several mitogenic, cytoprotective and angiogenic therapeutic applications of FGFs are already being explored, and the recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in bile acid, glucose and phosphate homeostasis has sparked renewed interest in the pharmacological potential of this family. This Review discusses traditional applications of recombinant FGFs and small-molecule FGF receptor kinase inhibitors in the treatment of cancer and cardiovascular disease and their emerging potential in the treatment of metabolic syndrome and hypophosphataemic diseases.
引用
收藏
页码：235 / 253
页数：19
相关论文
共 278 条
  • [1] The fibroblast growth factor-binding protein FGF-BP
    Abuharbeid, Shaker
    Czubayko, Frank
    Aigner, Achim
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2006, 38 (09) : 1463 - 1468
  • [2] Aigner A, 2001, INT J CANCER, V92, P510, DOI 10.1002/1097-0215(20010515)92:4<510::AID-IJC1227>3.0.CO
  • [3] 2-H
  • [4] Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Antoniou, Antonis C.
    Spurdle, Amanda B.
    Sinilnikova, Olga M.
    Healey, Sue
    Pooley, Karen A.
    Schmutzler, Rita K.
    Versmold, Beatrix
    Engel, Christoph
    Meindl, Alfons
    Arnold, Norbert
    Hofmann, Wera
    Sutter, Christian
    Niederacher, Dieter
    Deissler, Helmut
    Caldes, Trinidad
    Kampjarvi, Kati
    Nevanlinna, Heli
    Simard, Jacques
    Beesley, Jonathan
    Chen, Xiaoqing
    Neuhausen, Susan L.
    Rebbeck, Timothy R.
    Wagner, Theresa
    Lynch, Henry T.
    Isaacs, Claudine
    Weitzel, Jeffrey
    Ganz, Patricia A.
    Daly, Mary B.
    Tomlinson, Gail
    Olopade, Olufunmilayo I.
    Bium, Joanne L.
    Couch, Fergus J.
    Peterlongo, Paolo
    Manoukian, Siranoush
    Barile, Monica
    Radice, Paolo
    Szabo, Csilla I.
    Pereira, Lutecia H. Mateus
    Greene, Mark H.
    Rennert, Gad
    Leibkowicz, Flavio
    Barnett-Griness, Ofra
    Andrulis, Irene L.
    Ozcelik, Hilmi
    Gerdes, Anne-Marie
    Caligo, Maria A.
    Laitman, Yael
    Kaufman, Bella
    Milgrom, Roni
    Friedman, Eitan
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (04) : 937 - 948
  • [5] Aono Y, 2003, J BONE MINER RES, V18, pS16
  • [6] A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis
    Araya, K
    Fukumoto, S
    Backenroth, R
    Takeuchi, Y
    Nakayama, K
    Ito, N
    Yoshii, N
    Yamazaki, Y
    Yamashita, T
    Silver, J
    Igarashi, T
    Fujita, T
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (10) : 5523 - 5527
  • [7] FGF6 in myogenesis
    Armand, Anne-Sophie
    Laziz, Iman
    Chanoine, Christophe
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2006, 1763 (08): : 773 - 778
  • [8] FGF21 attenuates lipolysis in human adipocytes -: A possible link to improved insulin sensitivity
    Arner, Peter
    Pettersson, Amanda
    Mitchell, Pamela J.
    Dunbar, James D.
    Kharitonenkov, Alexei
    Ryden, Mikael
    [J]. FEBS LETTERS, 2008, 582 (12) : 1725 - 1730
  • [9] Testing clinical therapeutic angiogenesis using basic fibroblast growth factor (FGF-2)
    Aviles, RJ
    Annex, BH
    Lederman, RJ
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2003, 140 (04) : 637 - 646
  • [10] Badman MK, 2007, CELL METAB, V5, P426, DOI 10.1016/j.cmet.2007.05.002
12345678910