The coupling of alkylboronic acids with α-(trifluoromethyl)styrenes by lewis base/photoredox dual catalysis

被引：24

作者：

Chen, Yuefeng ^{[1
]}

Ni, Niannian ^{[1
]}

Cheng, Dongping ^{[2
]}

Xu, Xiaoliang ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China

[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

来源：

TETRAHEDRON LETTERS | 2020年 / 61卷 / 43期

基金：

美国国家科学基金会;

关键词：

Visible light photocatalysis; Alkylboronic acids; alpha-(Trifluoromethyl)styrenes; Gem-Difluoroalkenes; BAYLIS-HILLMAN DERIVATIVES; VISIBLE-LIGHT; PHOTOREDOX CATALYSIS; ALPHA-ALKYLATION; PHOTOCHEMICAL ACTIVITY; BORONIC ACIDS; FUNCTIONALIZATION; ALDEHYDES; DRIVEN; ORGANOCATALYSIS;

D O I：

10.1016/j.tetlet.2020.152425

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under Lewis base/photoredox dual catalysis, the defluorinative alkylation of alkylboronic acids with alpha-(trifluoromethyl)styrenes has been reported. In this system, both primary and secondary alkyl radicals produced by alkylboronic acids can react with alpha-(trifluoromethyl)styrenes to generate alkylated gem-difluoroalkenes. In general, the method has mild conditions, a wide substrate scope, and good functional group tolerance, which provides a new route for the synthesis of gem-difluoroalkenes. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：4

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