Limitations of parametric modeling of the left ventricle using first harmonic analysis: Possible role for gaussian modeling
被引:4
作者:
Hansen, Christopher L.
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机构:
Thomas Jefferson Univ, Cardiol Sect, Jefferson Heart Inst, Philadelphia, PA 19107 USAThomas Jefferson Univ, Cardiol Sect, Jefferson Heart Inst, Philadelphia, PA 19107 USA
Hansen, Christopher L.
[1
]
机构:
[1] Thomas Jefferson Univ, Cardiol Sect, Jefferson Heart Inst, Philadelphia, PA 19107 USA
Fourier (cosine) analysis of time activity curves (TAC) of radionuclide ventriculography (RVG) may oversimplify the TAC and has limitations. We identified 21 patients who had undergone 24 frame planar RVG with ejection fractions ranging from 8% to 76% (43% +/- A 19%). The TAC for each pixel was fitted to both a cosine and gaussian function then analyzed on a pixel-by-pixel basis then over the entire LV. Second, mathematical simulations were performed to analyze the stability of each fit in the presence of low amplitude and noise. The fit was slightly but significantly better for the gaussian compared to the cosine function (RMS gaussian 13.0% +/- A 2.5% vs 13.5% +/- A 2.1% cosine; P = .016). There was near exact correlation with amplitude and between gaussian mu and cosine phase. The SD of phase from the cosine fit correlated strongly with the SD of the mu from the gaussian fit. The proposed new measure of dyssynchrony, the sigma parameter of the gaussian fit, correlated with the SD of the cosine phase (r = 0.520, P = .016). Simulations showed gradual but modest deviation of the sigma parameter from the gaussian fit with lower amplitudes whereas the deviation of the calculated SD of phase increased exponentially with decreasing amplitude. First harmonic (cosine) fitting has significant limitations. Gaussian fitting is an alternative way to model the LV TAC. The sigma from the gaussian may provide additional information LV dyssynchrony and is less influenced by image noise. Gaussian fitting merits further evaluation for modeling LV function.
机构:
Christ Hosp, Ohio Heart & Vasc Ctr, Lindner Clin Trial Ctr, Cincinnati, OH 45219 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Chung, Eugene S.
Leon, Angel R.
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机构:
Emory Univ, Crawford Long Hosp, Atlanta, GA 30365 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Leon, Angel R.
Tavazzi, Luigi
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机构:
Osped Policlin San Matteo, Pavia, ItalyEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Tavazzi, Luigi
Sun, Jing-Ping
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机构:
Emory Univ, Crawford Long Hosp, Atlanta, GA 30365 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Sun, Jing-Ping
Nihoyannopoulos, Petros
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h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, London, England
Hammersmith Hosp, London, EnglandEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Nihoyannopoulos, Petros
Merlino, John
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h-index: 0
机构:
Emory Univ, Crawford Long Hosp, Atlanta, GA 30365 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Merlino, John
Abraham, William T.
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h-index: 0
机构:
Ohio State Univ, Ctr Heart, Columbus, OH 43210 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Abraham, William T.
Ghio, Stefano
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h-index: 0
机构:
Osped Policlin San Matteo, Pavia, ItalyEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Ghio, Stefano
Leclercq, Christophe
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h-index: 0
机构:
Univ Hosp, Rennes, FranceEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Leclercq, Christophe
Bax, Jeroen J.
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h-index: 0
机构:
Leiden Univ, Med Ctr, Leiden, NetherlandsEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Bax, Jeroen J.
Yu, Cheuk-Man
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h-index: 0
机构:
Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R ChinaEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Yu, Cheuk-Man
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Gorcsan, John, III
Sutton, Martin St John
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h-index: 0
机构:
Univ Penn, Med Ctr, Philadelphia, PA 19104 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Sutton, Martin St John
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De Sutter, Johan
Murillo, Jaime
论文数: 0引用数: 0
h-index: 0
机构:
Sentara Norfolk Gen Hosp, Norfolk, VA USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
Kerwin, WF
Botvinick, EH
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h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
Botvinick, EH
O'Connell, JW
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h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
O'Connell, JW
Merrick, SH
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h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
Merrick, SH
DeMarco, T
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h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
DeMarco, T
Chatterjee, K
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h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
Chatterjee, K
Scheibly, K
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h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
Scheibly, K
Saxon, LA
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h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
机构:
Christ Hosp, Ohio Heart & Vasc Ctr, Lindner Clin Trial Ctr, Cincinnati, OH 45219 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Chung, Eugene S.
Leon, Angel R.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Crawford Long Hosp, Atlanta, GA 30365 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Leon, Angel R.
Tavazzi, Luigi
论文数: 0引用数: 0
h-index: 0
机构:
Osped Policlin San Matteo, Pavia, ItalyEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Tavazzi, Luigi
Sun, Jing-Ping
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Crawford Long Hosp, Atlanta, GA 30365 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Sun, Jing-Ping
Nihoyannopoulos, Petros
论文数: 0引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, London, England
Hammersmith Hosp, London, EnglandEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Nihoyannopoulos, Petros
Merlino, John
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Crawford Long Hosp, Atlanta, GA 30365 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Merlino, John
Abraham, William T.
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Ctr Heart, Columbus, OH 43210 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Abraham, William T.
Ghio, Stefano
论文数: 0引用数: 0
h-index: 0
机构:
Osped Policlin San Matteo, Pavia, ItalyEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Ghio, Stefano
Leclercq, Christophe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, Rennes, FranceEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Leclercq, Christophe
Bax, Jeroen J.
论文数: 0引用数: 0
h-index: 0
机构:
Leiden Univ, Med Ctr, Leiden, NetherlandsEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Bax, Jeroen J.
Yu, Cheuk-Man
论文数: 0引用数: 0
h-index: 0
机构:
Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R ChinaEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Yu, Cheuk-Man
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h-index:
机构:
Gorcsan, John, III
Sutton, Martin St John
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Med Ctr, Philadelphia, PA 19104 USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
Sutton, Martin St John
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h-index:
机构:
De Sutter, Johan
Murillo, Jaime
论文数: 0引用数: 0
h-index: 0
机构:
Sentara Norfolk Gen Hosp, Norfolk, VA USAEmory Univ, Crawford Long Hosp, Atlanta, GA 30365 USA
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
Kerwin, WF
Botvinick, EH
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
Botvinick, EH
O'Connell, JW
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
O'Connell, JW
Merrick, SH
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
Merrick, SH
DeMarco, T
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
DeMarco, T
Chatterjee, K
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
Chatterjee, K
Scheibly, K
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
Scheibly, K
Saxon, LA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA