Regulation of mast cell activation by complement-derived peptides

被引：36
|
作者：
Erdei, A
Andrásfalvy, M
Péterfy, H
Tóth, G
Pecht, I
机构：
[1] Eotvos Lorand Univ, Dept Immunol, Res Grp, Hungarian Acad Sci, H-1117 Budapest, Hungary
[2] Univ Szeged, Dept Med Chem, Szeged, Hungary
[3] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
来源：
IMMUNOLOGY LETTERS | 2004年 / 92卷 / 1-2期
关键词：
C3a; C5a; anaphylatoxic peptides; activation; inhibition; serosal and mucosal type mast cells;
D O I：
10.1016/j.imlet.2003.11.019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
It is known for more than 25 years that the complement-derived anaphylatoxic peptides, C3a, C4a and C5a are potent activators of basophils and certain types of mast cells. Although tissue distribution of receptors for C3a and C5a well exceeds myeloid cells, apparently they are not expressed on mucosal type mast cells, consequently these cells are not activated by C3a and C5a. Our results do however demonstrate that C3a and peptides related to this complement activation product are able to inhibit FcepsilonRI-clustering induced activation of mucosal type mast cells-such as RBL-2H3 cells and bone-marrow derived mast cells. Based on the current results we propose the presence of separate "activator" and "inhibitor" sequence motifs in C3a which are in balance under physiologic conditions. (C) 2004 Elsevier B.V. All rights reserved.
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页码：39 / 42
页数：4
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