Tailor-made drug carrier: Comparison of formation-dependent physicochemical properties within self-assembled aggregates for an optimal drug carrier

被引：13

作者：

Hayashi, Keita ^{[1
]}

Iwai, Hideka ^{[1
]}

Kamei, Toshiyuki ^{[1
]}

Iwamoto, Kaede ^{[2
]}

Shimanouchi, Toshinori ^{[2
]}

Fujita, Sakiko ^{[3
]}

Nakamura, Hidemi ^{[1
]}

Umakoshi, Hiroshi ^{[4
]}

机构：

[1] Nara Coll, Natl Inst Technol, Dept Chem Engn, 22 Yata Yamatokoritama Cyo, Nara 6391080, Japan

[2] Okayama Univ, Grad Sch Environm & Life Sci, Div Environm Sci, 3-1-1 Tsushima Naka, Okayama 7008530, Japan

[3] Nara Inst Sci Technol, Grad Sch Mat Sci, 8916-5 Takayama, Ikoma, Nara 6300192, Japan

[4] Osaka Univ, Grad Sch Engn Sci, Div Chem Engn, 1-3 Machikaneyama Cho, Toyonaka, Osaka 5608531, Japan

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2017年 / 152卷

基金：

日本学术振兴会;

关键词：

Self-assembly; Tailor-made drug carrier; Vesicle; Micelle; SPAN; 80; VESICLES; GENE DELIVERY; PARTICLE-SIZE; CHAIN-LENGTH; CELL-LINE; SURFACE; LIPOSOMES; MEMBRANE; NANOPARTICLES; WATER;

D O I：

10.1016/j.colsurfb.2017.01.012

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Self-assembled surfactant aggregates, such as micelles and vesicles, have been investigated for their application as drug carriers in the treatment of various diseases. However, the characteristics that decide which aggregate is the best drug carrier for each disease have not yet been clarified. In order to design an optimal drug carrier for each disease, various kinds of self-assembled aggregates, such as spherical micelles, lens-like vesicles, and tube-like vesicles, were evaluated by "multiple techniques" including dynamic light scattering, differential scanning calorimetry, nuclear magnetic resonance spectroscopy, and fluorescence measurement using the Laurdan probe. These studies led to the compilation of a database on the formation-dependent properties of self-assembled aggregates. As the relationship between physicochemical properties of self-assembled aggregates and their functions as drug carriers have been extensively reported, this database can be utilized for designing an optimal drug carrier, i.e., a tailor-made drug carrier. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：269 / 276

页数：8

共 60 条

[41] STRUCTURE OF MICELLAR SOLUTIONS OF SOME AMPHIPHILIC COMPOUNDS IN PURE WATER AS DETERMINED BY ABSOLUTE SMALL-ANGLE X-RAY SCATTERING TECHNIQUES [J].